- Professional overview
Dr. Bernadette Capili’s area of research focuses on cardiovascular disease prevention and healthy weight management. Dr. Capili has examined the effects of diet on the metabolic complications of HIV and metabolic markers to predict cardiovascular disease in HIV. Her research also includes investigating traditional methods of healing such as herbal therapies and acupuncture to reduce cardiovascular risk in HIV. As a clinical researcher and clinician, Dr. Capili has an emphasis on identifying patient related outcomes in all of her studies to determine the efficacy of various treatment modalities. Her goal is to identify and to test outcome measures, which can be translated across clinical settings and healthcare disciplines. Dr. Capili has a track record of federal funding from the National Institutes of Health and Department of Health and Human Services. Dr. Capili is the recipient of several prestigious awards including the Nicholas Rango HIV Primary Care Fellowship, sponsored by the New York States AIDS Institutes, National Research Service Award Individual Pre-doctoral Fellowship, sponsored by the National Institutes of Health (NIH), the Columbia University Dean’s Distinguished Post-Doctoral Research Fellowship, Herbert Irving Research Fellows Program, sponsored by the Clinical Translation Science Award/NIH/National Center Research Resources, and the Epidemiology and Prevention of Cardiovascular Disease program, sponsored by the American Heart Association. Dr. Capili was nominated and appointed to serve as an advisory member for the American Heart Association/HIV Academy of Medicine on HIV and Cardiovascular Disease. She is also a reviewer for numerous peer-reviewed journals and scientific reviewer for federal agencies. Additionally, her work has received recognition from the Association of Nurses in AIDS Care as the recipient of the “Outstanding Article of the Year Award” and “Research Article of the Year Award.”
PhD, Columbia UniversityMS, Adult Nurse Practitioner, Columbia UniversityBS, Nursing, Michigan State University
- Honors and awards
Nominated, 23rd Annual Nurse Research Recognition Award. Association for Nurses in AIDS Care (2010)Fellow, 34th Seminar on the Epidemiology and Prevention of Cardiovascular Disease, Council on Epidemiology and Prevention of the American Heart Association (2008)Florence Irving Fellow, Columbia University Medical Center. Clinical Translational Science Award (2008)Florence Irving Fellow, Columbia University Medical Center. Clinical Translational Science Award (2007)Columbia University School of Nursing - Distinguished Young Alumni Award (2007)Columbia University School of Nursing - Center for AIDS Research: Award for Service and Contribution (2002)Association of Nurses in AIDS Care: Outstanding Article - JANAC (1999)Columbia University School of Nursing/Center for Health Policy: Village Center for Care Scholarship (Tuition Support) (1998)New York State AIDS Institute/Nicholas A. Rango HIV Clinical Scholars Fellowship Recipient (1997)New York State AIDS Institute/Nicholas A. Rango HIV Clinical Scholars Fellowship Recipient (1996)St. Joseph Mercy Hospital: Mercy Values Award (1992)
Primary careAdult healthNon-communicable diseaseInfectious diseaseComplementary/integrative health
- Professional membership
American Nursing AssociationAssociation of Nurses in AIDS CarePreventive Cardiology Nursing AssociationSigma Theta Tau, Upsilon ChapterAmerican Academy for Nurse Practitioners
Herbal Supplements: Talking with your PatientsAnastasi, J.K., Chang, M., & Capili, B. (2011). The Journal for Nurse Practitioners 7, (29-35). 10.1016/j.nurpra.2010.06.004 Elsevier BV.
Traditional Chinese medicine and human immunodeficiency virus-associated neuropathyAnastasi, J.K., Chang, M., Capili, B., & Dawes, N. (2011). Journal of Chinese Medicine (16-20).
Peripheral neuropathy is one of the most common neurological complications of human immunodeficiency virus (HIV) infection and continues to impact people living with HIV/AIDS. The pain associated with peripheral neuropathy can be severe and debilitating. Most pharmacological agents are inadequate in symptom management and are accompanied by adverse side-effects. Acupuncture and moxibustion offer treatment approaches that can reduce HIV symptoms and/or the side-effects of anti-retroviral therapy and improve patients' quality of life.
Acupuncture/moxibustion RCT for distal sensory peripheral neuropathy in HIV/AIDS: Rationale, design, methods, procedures and logisticsAnastasi, J.K., Capili, B., Chung, A.M., & Hammerschlag, R. (2010). European Journal of Chinese Medicine 6, (40-52).
Distal sensory peripheral neuropathy is a common neurological complication experienced by people living with the human immunodeficiency virus (HIV). Traditional Chinese medicine (TCM) may offer effective interventions in the management of its symptoms. To improve the quality and transparency of reporting acupuncture clinical trials, the Consolidated Standards of Reporting Trials (CONSORT) guidelines were developed in 1996 and the Standards for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA) recommendations were introduced in 2001. Incorporating international guidelines, this paper describes the development of a RCT including rationale, design, methods, procedures and logistics for a pilot study aimed at evaluating acupuncture and moxibustion for neuropathy associated with HIV. Using STRICTA guidelines as a template, aspects of clinical research design are explored to further optimise future studies of TCM.
Adverse event reporting in acupuncture clinical trials focusing on pain.Capili, B., Anastasi, J. K., & Geiger, J. N. (2010). The Clinical journal of pain 26, (43-8). 10.1097/AJP.0b013e3181b2c985
To review the quality of adverse event reporting for published randomized controlled trials (RCTs) focusing on acupuncture for pain reduction. With the release of the Consolidated Standards of Reporting Trials (CONSORT) in 2001, the quality of published RCTs has improved. To improve reporting on adverse events, CONSORT expanded the section on harms (adverse events) in 2004. This paper evaluates whether the updated harms guidelines have been implemented in RCTs evaluating acupuncture for pain relief.
Distal Sensory Peripheral Neuropathy in HIV: A Case StudyAnastasi, J.K., Smolowitz, J., & Capili, B. (2009). Clinical Scholars Review 2, (13-18). 10.1891/1939-2095.2.1.13 Springer Publishing Company.
Body mass index and nutritional intake in patients with HIV and chronic diarrhea: a secondary analysis.Capili, B., & Anastasi, J. K. (2008). Journal of the American Academy of Nurse Practitioners 20, (463-70). 10.1111/j.1745-7599.2008.00349.x
The purpose of this study was to examine the differences in nutritional intake and body mass index (BMI) in HIV patients with chronic diarrhea via secondary analysis of patients' nutritional diaries. A secondary purpose was to evaluate the quality of diets against national dietary guidelines.
Screening and assessment of coronary heart disease in HIV-infected patients.Hsue, P. Y., Squires, K., Bolger, A. F., Capili, B., Mensah, G. A., Temesgen, Z., … (2008). Circulation 118, (e41-7). 10.1161/CIRCULATIONAHA.107.189626
Disorders of glucose metabolism in the context of human immunodeficiency virus infection.Larson, R., Capili, B., Eckert-Norton, M., Colagreco, J. P., & Anastasi, J. K. (2006). Journal of the American Academy of Nurse Practitioners 18, (92-103). 10.1111/j.1745-7599.2006.00109.x
To discuss the pathophysiology and the current treatment approaches for the dysregulation of glucose metabolism in the context of human immunodeficiency virus (HIV) infection.
HIV and hyperlipidemia: current recommendations and treatment.Capili, B., & Anastasi, J. K. (2006). Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 15, (14-9, 35; quiz 20).
In recent years, CVD risk factors have been recognized among individuals living with HIV/AIDS (Dube et al., 2003) and have been associated with the medication regimen (HAART) used to manage the diseases. A specific class of HIV medication, protease inhibitors, has been implicated in elevating serum levels of triglyceride and cholesterol in treated individuals (Green, 2002; Penzak & Chuck, 2000). However, current treatments for hyperlipidemia in HIV are not always effective and can be dose-limited due to interactions with HAART regimens (Currier, 2002). Dietary guidelines by the NCEP have been recommended as the first-line approach to managing this condition. Well-controlled studies are needed to test the effectiveness of the NCEP diet on HIV-positive individuals. Published studies have focused primarily on dietary counseling and have lacked randomization, control groups, and adequate description of the counseling intervention. Because the mechanism associated with dyslipidemia and HAART is not fully understood, rigorously controlled dietary studies may provide the opportunity to investigate how diet metabolically affects lipid levels during HAART treatment.
Symptom Management of HIV-Related Diarrhea by Using Normal Foods: A Randomized Controlled Clinical TrialAnastasi, J.K., Capili, B., Kim, G., McMahon, D., & Heitkemper, M.M. (2006). Journal of the Association of Nurses in AIDS Care 17, (47-57). 10.1016/j.jana.2006.01.005 Elsevier BV.
Clinical trial recruitment and retention of a vulnerable population: HIV patients with chronic diarrhea.Anastasi, J. K., Capili, B., Kim, G. H., & Chung, A. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 28, (463-8).
This article describes the recruitment and retention strategies implemented for a prospective, randomized, clinical trial conducted at a single study facility. The purpose of the study was to examine the effects of a nutritional intervention to reduce the episodes of diarrhea in patients with the human immunodeficiency virus/acquired immune deficiency syndrome. This article reviews the challenges faced by the research team during the conduct of the study and discusses the approaches implemented to reduce the barriers to study participation.
Developing an integrative therapies in primary care program.Anastasi, J. K., Capili, B., & Schenkman, F. Nurse educator 34, (271-5). 10.1097/NNE.0b013e3181bc747a
The authors describe the development and incorporation of an integrative therapies subspecialty curriculum into a graduate nursing education program. Specialized education in integrative therapies prepares nursing students more thoroughly for primary care practice because many patients now use what is called complementary and alternative medicine in conjunction with standard medical care. Students learn to determine the safety, efficacy, and cultural significance of complementary and alternative medicine practices of their diverse patient population.
HIV and general cardiovascular risk.Capili, B., Anastasi, J. K., & Ogedegbe, O. The Journal of the Association of Nurses in AIDS Care : JANAC 22, (362-75). 10.1016/j.jana.2010.12.002
The incidence of cardiovascular disease (CVD) is increasing in HIV-infected people. Risk factors such as hyperlipidemia, impaired glucose tolerance, and insulin resistance have become common. CVD in HIV may also be related to nontraditional risk factors including accumulation of visceral fat, inflammation secondary to HIV, and effects of some antiretroviral drugs. This cross-sectional study described the CVD risk factors of 123 adults living with HIV and calculated the 10-year estimate for general cardiovascular risk score. Results showed that approximately 25% of the participants were considered to be at high risk for developing CVD in the next 10 years. Increased waist circumference and longer duration of smoking habit were associated with elevated general cardiovascular risk scores. Similar to the general population, most of the identified risks could be modified through lifestyle management.
Nausea and vomiting in HIV/AIDS.Anastasi, J. K., & Capili, B. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 34, (15-24). 10.1097/SGA.0b013e31820b256a
HIV infection has become a chronic illness with the availability of potent antiretroviral agents. Many of the agents used to manage HIV, however, have been associated with distressing symptoms such as nausea and vomiting posing challenges to maintain adherence to therapy and quality of life. This article highlights the mechanism, evaluation, and management of HIV-associated nausea and vomiting. Supportive symptom management information is also presented.