Jacquelyn Taylor, PhD, RN, PNP-BC, FAHA, FAAN, professor of nursing, medicine, and population health, is the inaugural Vernice D. Ferguson Professor in Health Equity. Taylor’s work focuses on the interaction of –omics and social factors that contribute to health disparities for common chronic conditions among underrepresented minority populations in the US and vulnerable populations abroad. Her R01 "Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure - InterGen" examined the gene-environment and DNAm-environment interactions of perceived racism and discrimination, parenting stress, and maternal mental health on blood pressure on African American mothers and their young children. Taylor is also conducting a study on the genomics of lead poisoning in Flint, MI. She was awarded the Presidential Early Career Award for Scientists and Engineers (PECASE) by President Barack Obama in 2017, the highest honor awarded by the federal government to scientists and engineers, where she will examine next-generation sequencing-environment interactions on blood pressure among African Americans. Additionally, Taylor is co-PI and co-director of the administrative core of a NINR-funded P20 Exploratory Center on Precision Health in Diverse Populations. Her long-term goals are to develop nursing interventions to reduce and prevent omic-environment risks associated with health disparities in diverse populations across the lifespan.
Prior to joining the faculty at NYU, Taylor was Associate Professor with Tenure and Associate Dean of Diversity and Inclusion at the Yale School of Nursing.
She received a B.S.N., M.S.N. (Pediatric Nurse Practitioner), and Ph.D., from Wayne State University College of Nursing in Detroit. Taylor also completed a postdoctoral fellowship in Urban Health Aging at the Wayne State University Institute of Gerontology. Taylor has completed additional training in Molecular Genetics at Georgetown University and Cardiovascular Genetic Epidemiology at Washington University in St. Louis.
Publications can be found on the Google Scholar and/or MyNCBI links below.
Ph.D. Wayne State UniversityM.S.N. Wayne State UniversityB.S.N. Wayne State University
Honors and awards
Nurse Researcher of the Year Award. Greater New York City Black Nurses Association. (2019)Hall of Fame Award. American Nurses Association - New York. (2019)Vernice D. Ferguson Professor in Health Equity Endowed Chair (2018)Fellow, New York Academy of Medicine (2018)Mary Mahoney Award- American Nurses Association (2018)PECASE: Presidential Early Career Award for Scientists and Engineers (2017)The New Haven Club of the The National Association of Negro Business and Professional Women’s Clubs, Inc. Professional Award Recipient (2015)Massachusetts Institute of Technology (MIT) - MLK Visiting Professor (2015)Fellow American Heart Association (2015)International Society of Nurses in Genetics (ISONG) Founders Award for Outstanding Genetics Research and Scholarship (2011)Fellow American Academy of Nursing (2011)
American Academy of NursingAmerican Heart AssociationInternational Society of Nurses in GeneticsNational Association of Pediatric Nurse PractitionersSigma Theta Tau International Honor Society of NursingNew York Academy of Medicine
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN StudyAbstractAfrican American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjusting for smoking, hypertension diagnosis history, and socioeconomic factors (education, marital status, household income), a 1 kg/m2 increase in BMI is associated with 0.14 years increment of DNAm AA (95% CI: (0.08, 0.21)). The conclusion: in African American women, high BMI is independently associated with saliva-based DNA methylation age acceleration, after adjusting for smoking, hypertension, and socioeconomic status. This finding supports that high BMI accelerates biological aging, and plays a key role in age-related disease outcomes among African American women.
Genomics of reproductive traits and cardiometabolic disease risk in African American WomenAbstractBackground Age at menarche and age at natural menopause occur significantly earlier in African American women than in other ethnic groups. African American women also have twice the prevalence of cardiometabolic disorders related to the timing of these reproductive traits. Objectives The objectives of this integrative review were to (a) summarize the genome-wide association studies of reproductive traits in African American women, (b) identify genes that overlap with reproductive traits and cardiometabolic risk factors in African American women, and (c) propose biological mechanisms explaining the link between reproductive traits and cardiometabolic risk factors. Methods PubMed was searched for genome-wide association studies of genes associated with reproductive traits in African American women. After extracting and summarizing the primary genes, we examined whether any of the associations with reproductive traits had also been identified with cardiometabolic risk factors in African American women. Results Seven studies met the inclusion criteria. Associations with both reproductive and cardiometabolic traits were reported in or near the following genes: FTO, SEC16B, TMEM18, APOE, PHACTR1, KCNQ1, LDLR, PIK3R1, and RORA. Biological pathways implicated include body weight regulation, vascular homeostasis, and lipid metabolism. Discussion A better understanding of the genetic basis of reproductive traits in African American women may provide insight into the biological mechanisms linking variation in these traits with increased risk for cardiometabolic disorders in this population.
Novel DNA methylation sites associated with cigarette smoking among African AmericansAbstractIntroduction: Cigarette smoking has been associated with adverse health outcomes for mothers and children and is a major contributor to heart disease. Although cigarette smoking is known to affect the epigenome, few studies have been done in African American populations. In this study, we investigated the association between cigarette smoking and DNA methylation (DNAm) among African Americans from the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study (InterGEN), and the Genetic Epidemiology Network of Arteriopathy (GENOA). Methods: The InterGEN study aims to examine the effects of genetic and psychological factors on blood pressure among African American women and their children. Current cigarette smoking was assessed at baseline. DNAm of saliva was assessed using the 850K EPIC Illumina BeadChip for Epigenome-Wide Association analyses. A replication study was conducted among 1100 participants in the GENOA study using the same BeadChip. Results: After controlling for age, body mass index, population structure and cell composition, 26 epigenome-wide significant sites (FDR q < 0.05) were identified, including the AHRR and PHF14 genes associated with atherosclerosis and lung disease, respectively. Six novel CpG sites were discovered in the InterGEN sample and replicated in the GENOA sample. Genes mapped include RARA, FSIP1, ALPP, PIK3R5, KIAA0087, and MGAT3, which were largely associated with cancer development. Conclusion: We observed significant epigenetic associations between smoking and disease-associated genes (e.g., cardiovascular disease, lung cancer). Six novel CpG sites were identified and replicated across saliva and blood samples.
NuRsing Research in the 21st Century: R You Ready?AbstractNurse scientists are adept at translating findings from basic science into useful clinical- and community-based interventions to improve health. Over time, the focus of some nursing research has grown to include the assessment and evaluation of genomic and other output from high-throughput, or “omic,” technologies as indicators related to health and disease. To date, the growth in the application of omics technologies in nursing research has included calls to increase attention to omics in nursing school curricula and educational training opportunities, such as the Summer Genetics Institute offered by the National Institute of Nursing Research. However, there has been scant attention paid in the nursing literature to the complexity of data analysis or issues of reproducibility related to omics studies. The goals of this article are to (1) familiarize nurse scientists with tools that encourage reproducibility in omics studies, with a focus on the free and open-source data processing and analysis pipeline, and (2) provide a baseline understanding of how these tools can be used to improve collaboration and cohesion among interdisciplinary research team members. Knowledge of these tools and skill in applying them will be important for communication across disciplines and imperative for the advancement of omics research in nursing.
Using Genetic Burden Scores for Gene-by-Methylation Interaction Analysis on Metabolic Syndrome in African AmericansAbstractWith the rapid advancement of omics-based research, particularly big data such as genome- and epigenome-wide association studies that include extensive environmental and clinical variables, data analytics have become increasingly complex. Researchers face significant challenges regarding how to analyze multifactorial data and make use of the findings for clinical translation. The purpose of this article is to provide a scientific exemplar for use of genetic burden scores as a data analysis method for studies with both genotype and DNA methylation data in which the goal is to evaluate associations with chronic conditions such as metabolic syndrome (MetS). This study included 739 African American men and women from the Genetic Epidemiology Network of Arteriopathy Study who met diagnostic criteria for MetS and had available genetic and epigenetic data. Genetic burden scores for evaluated genes were not significant after multiple testing corrections, but DNA methylation at 2 CpG sites (dihydroorotate dehydrogenase cg22381196 pFDR =.014; CTNNA3 cg00132141 pFDR =.043) was significantly associated with MetS after controlling for multiple comparisons. Interactions between the marginally significant CpG sites and burden scores, however, were not significant. More work is required in this area to identify intermediate biological pathways influenced by environmental, genetic, and epigenetic variation that may explain the high prevalence of MetS among African Americans. This study does serve, however, as an example of the use of the genetic burden score as an alternative data analysis approach for complex studies involving the analysis of genetic and epigenetic data simultaneously.
Improving -Omics-Based Research and Precision Health in Minority Populations: Recommendations for Nurse ScientistsAbstractPurpose: The purpose of this article is to provide an overview of the role of nurse scientists in -omics-based research and to promote discussion around the conduct of -omics-based nursing research in minority communities. Nurses are advocates, educators, practitioners, scientists, and researchers, and are crucial to the design and successful implementation of -omics studies, particularly including minority communities. The contribution of nursing in this area of research is crucial to reducing health disparities. Methods: In this article, challenges in the conduct of -omics-based research in minority communities are discussed, and recommendations for improving diversity among nurse scientists, study participants, and utilization of training and continuing education programs in -omics are provided. Findings and Conclusions: Many opportunities exist for nurses to increase their knowledge in -omics and to continue to build the ranks of nurse scientists as leaders in -omics-based research. In order to work successfully with communities of color, nurse scientists must advocate for participation in the Precision Medicine Initiative, improve representation of nurse faculty of color, and increase utilization of training programs in -omics and lead such initiatives. Clinical Relevance: All nursing care has the potential to be affected by the era of -omics and precision health. By taking an inclusive approach to diversity in nursing and -omics research, nurses will be well placed to be leaders in reducing health disparities through research, practice, and education.
Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive SibshipsAbstractIntroduction: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations. Methods: The purpose of this study was to determine whether single-nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) differences contribute to lipid variation among African Americans ([AAs], N = 739) in the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Results: Previous meta-analyses identified 161 SNPs that are associated with lipid traits in populations of EA. We evaluated these SNPs and 66 DNAm sites within the genes containing the SNPs in the GENOA cohort using linear mixed-effects modeling. We did not identify any significant associations of SNPs or DNAm with serum lipid levels. These results suggest that the SNPs identified as being significant for lipid levels through the EA genome-wide association studies may not be significant across AA populations. Conclusions: Reductions in morbidity and mortality due to variation in lipids among AAs may be achieved through a better understanding of the genetic and epigenetic factors associated with serum lipid levels for early and appropriate screening. Further large-scale studies specifically within AA and other non-EA populations are warranted.
Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.AbstractPlasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations.
Nursing genetics and genomics: The International Society of Nurses in Genetics (ISONG) surveyAbstractBackground: The International Society of Nursing in Genetics (ISONG) fosters scientific and professional development in the discovery, interpretation, and application of genomic information in nursing research, education, and clinical practice. Objectives: Assess genomic-related activities of ISONG members in research, education and practice, and competencies to serve as global leaders in genomics. Design: Cross-sectional survey (21-items) assessing genomic-related training, knowledge, and practice. Settings: An email invitation included a link to the anonymous online survey. Participants: All ISONG members (n = 350 globally) were invited to partake. Methods: Descriptive statistics and Wilcoxon Rank Sum Test for between-group comparisons. Results: Respondents (n = 231, 66%), were mostly Caucasian, female, with a master's degree or higher. Approximately 70% wanted to incorporate genomics in research, teaching, and practice. More than half reported high genomic competency, and over 95% reported that genomics is relevant the next 5 years. Conclusions: Findings provide a foundation for developing additional educational programs for an international nursing workforce in genomics.
Nursing genetics and genomics: The International Society of Nurses in Genetics (ISONG) survey.AbstractThe International Society of Nursing in Genetics (ISONG) fosters scientific and professional development in the discovery, interpretation, and application of genomic information in nursing research, education, and clinical practice.