Leon Chen headshot

Leon Chen


Clinical Assistant Professor

1 212 998 5326

433 First Avenue
New York, NY 10010
United States

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Professional overview

Dr.​ ​Leon​ ​Chen​ ​is​ ​a​ ​board​ ​certified​ ​Adult/Gerontology​ ​Acute​ ​Care​ ​Nurse​ ​Practitioner​ ​with background​ ​in​ ​emergency​ ​and​ ​critical​ ​care​ ​medicine.​ ​He​ ​holds​ ​specialty​ ​board​ ​certifications​ ​in both​ ​emergency​ ​and​ ​critical​ ​care​ ​nursing.​ ​With​ ​extensive​ ​experience​ ​in​ ​invasive​ ​procedures​ ​and advanced​ ​resuscitation​ ​methods,​ ​he​ ​is​ ​also​ ​a​ ​strong​ ​proponent​ ​of​ ​utilizing​ ​point​ ​of​ ​care ultrasonography​ ​to​ ​rapidly​ ​delineate​ ​differential​ ​diagnoses​ ​and​ ​to​ ​guide​ ​resuscitation.​ ​Having earned​ ​a​ ​certificate​ ​of​ ​completion​ ​in​ ​critical​ ​care​ ​ultrasonography​ ​from​ ​the​ ​American​ ​College​ ​of Chest​ ​Physicians,​ ​Dr.​ ​Chen​ ​is​ ​active​ ​in​ ​critical​ ​care​ ​ultrasonography​ ​education​ ​and​ ​aside​ ​from teaching​ ​NP/PA,​ ​resident​ ​physicians​ ​and​ ​critical​ ​care​ ​fellows​ ​at​ ​the​ ​bedside,​ ​he​ ​has​ ​also​ ​been​ ​a course​ ​planner/faculty​ ​for​ ​the​ ​annual​ ​critical​ ​care​ ​ultrasound​ ​workshop​ ​for​ ​NP/PA​ ​and​ ​MDs​ ​held at​ ​Memorial​ ​Sloan​ ​Kettering​ ​Cancer​ ​Center​ ​since​ ​2016.​ ​He​ ​has​ ​also​ ​created​ ​an​ ​ultrasound training​ ​curriculum​ ​for​ ​critical​ ​care​ ​NP​ ​and​ ​PAs​ ​at​ ​Memorial​ ​Sloan​ ​Kettering​ ​Cancer​ ​Center​ ​and serves​ ​as​ ​a​ ​liaison​ ​between​ ​Cardiology​ ​and​ ​Critical​ ​Care​ ​Medicine​ ​Service​ ​to​ ​streamline​ ​critical cardiac​ ​diagnosis​ ​and​ ​management.​ ​Dr.​ ​Chen​ ​has​ ​numerous​ ​publications​ ​in​ ​peer​ ​reviewed journals​ ​on​ ​the​ ​topics​ ​of​ ​sedation,​ ​delirium,​ ​sepsis,​ ​resuscitation​ ​and​ ​critical​ ​care​ ​ultrasonography and​ ​is​ ​currently​ ​an​ ​Editorial​ ​Board​ ​Member​ ​of​ ​the​ ​journal​ ​​Critical​ ​Care​ ​Nursing​ ​Quarterly​. Finally,​ ​Dr.​ ​Chen​ ​has​ ​been​ ​an​ ​adjunct​ ​clinical​ ​instructor/ACNP​ ​preceptor​ ​for​ ​NYU​ ​since​ ​2013 and​ ​is​ ​a​ ​frequent​ ​speaker​ ​at​ ​institutional​ ​critical​ ​care​ ​forums​ ​and​ ​professional​ ​organizations’ educational​ ​symposiums​ ​and​ ​conferences.​ ​Dr.​ ​Chen​ ​hopes​ ​to​ ​bring​ ​his​ ​clinical​ ​experience​ ​to NYU​ ​Rory​ ​Meyers​ ​College​ ​of​ ​Nursing​ ​and​ ​incorporate​ ​point​ ​of​ ​care​ ​ultrasonography​ ​teaching into​ ​the​ ​ACNP​ ​program.  

Doctor of Nursing Practice, Chatham University
Masters of Science in Adult/Gerontology Acute Care NP, NYU Rory Meyers College of Nursing
Bachelors​ ​of​ ​Science​ ​-​ ​NYU​ ​Rory​ ​Meyers​ ​College​ ​of​ ​Nursing​
Professional membership
American​ ​College​ ​of​ ​Chest​ ​Physicians
Society​ ​of​ ​Critical​ ​Care​ ​Medicine
American​ ​Academy​ ​of​ ​Nurse​ ​Practitioners
American​ ​Association​ ​of​ ​Critical-Care​ ​Nurses
Sigma Theta Tau Honor Society of Nursing
Editorial Board Member of Critical Care Nursing Quarterly
Co-chair of Education Committee, American Assembly of Men in Nursing - Men in Nursing

A Lung Cancer Patient With Respiratory Insufficiency and Hemodynamic Instability.

Chen, L. L., Finan, M., Mead, E., & Halpern, N. A. (2018). Chest 153, (e49-e52). 10.1016/j.chest.2017.10.048 Elsevier BV.

Point of care ultrasonography in emergency and critical care medicine

Chen, L. & Malek, T. (2018). Crit Care Nurs Q 41, (94-101). 10.1097/CNQ.0000000000000190


Chen, L., Mead, E., D’Agostino, R., & Halpern, N. (2017). Critical Care Medicine 46, (163). 10.1097/01.ccm.0000528380.35273.a9 Ovid Technologies (Wolters Kluwer Health).


Gale, M., Thandra, K., Synborski, E., Chen, L., Mead, E., Halpern, N., & Voigt, L. (2017). Critical Care Medicine 46, (232). 10.1097/01.ccm.0000528513.02893.59 Ovid Technologies (Wolters Kluwer Health).

A Patient on Airway Pressure Release Ventilation With Sudden Hemodynamic Collapse.

Chen, L. L., Mead, E., & Gale, M. J. (2017). Chest 152, (e7-e9). 10.1016/j.chest.2017.01.041

Managing hypocalcemia in massive blood transfusion.

Lim, F., Chen, L. L., & Borski, D. (2017). Nursing 47, (26-32). 10.1097/01.NURSE.0000515501.72414.e3

Recognizing and treating vasospastic angina.

Chen, L., & Lim, F. (2016). The Nurse practitioner 41, (1-3). 10.1097/01.NPR.0000502795.96478.bb

Propofol infusion syndrome: a rare but lethal complication.

Chen, L., & Lim, F. A. (2014). Nursing 44, (11-3). 10.1097/01.NURSE.0000456376.94907.11

Don't Go Chasing Waterfalls: Excessive Fluid Resuscitation in Severe Sepsis and Septic Shock.

Chen, L. Critical care nursing quarterly 39, (34-7). 10.1097/CNQ.0000000000000094

Aggressive fluid resuscitation is the mainstay therapy in modern sepsis management. Its efficacy was demonstrated in the landmark study by Emmanuel Rivers in 2001. However, more recent evidence largely shows that a positive fluid balance increases mortality in critically ill patients with sepsis. This article examines the theoretical benefits of fluid resuscitation and physiological responses to it that may negatively affect patients' outcome.

Factors Influencing Weaning Older Adults From Mechanical Ventilation: An Integrative Review.

Stieff, K. V., Lim, F., & Chen, L. Critical care nursing quarterly 40, (165-177). 10.1097/CNQ.0000000000000154

This study aim was to describe the influences that affect weaning from mechanical ventilation among older adults in the intensive care unit (ICU). Adults older than 65 years comprised only 14.5% of the US population in 2014; however, they accounted up to 45% of all ICU admissions. As this population grows, the number of ICU admissions is expected to increase. One of the most common procedures for hospitalized adults 75 years and older is mechanical ventilation. An integrative review methodology was applied to analyze and synthesize primary research reports. A search for the articles was performed using the PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases; using the keywords and Boolean operators "older adults," "weaning," "mechanical ventilation," and intensive care unit. Although physiologic changes that occur with aging place older adults at higher risk for respiratory complications and mortality, there are many factors, other than chronological age, that can determine a patient's ability to be successfully weaned from mechanical ventilation. Of the 6 studies reviewed, all identified various predictors of weaning outcome, which included maximal inspiratory pressure, rapid shallow breathing index, fluid balance, comorbidity burden, severity of illness, emphysematous changes, and low serum albumin. Age, in and of itself, is not a predictor of weaning from mechanical ventilation. More studies are needed to describe the influences affecting weaning older adults from mechanical ventilation.

Follow me down the K-hole: ketamine and its modern applications.

Chen, L., & Malek, T. Critical care nursing quarterly 38, (211-6). 10.1097/CNQ.0000000000000064

Ketamine is a versatile anesthetic agent that has been in use since the Vietnam War. Its popularity grew in war time due to its unique pharmacological properties, yet its use dwindled because of some of its adverse effects. However, in specialty areas, ketamine remains the drug of choice and its benefit far outweighs its risk. In our review, we outline the history of ketamine, its pharmacological properties, and its modern applications in various arenas.

Glycocalyx in Sepsis Resuscitation.

Chen, L. Critical care nursing quarterly 39, (38-41). 10.1097/CNQ.0000000000000095

Starling's forces are fundamental to our understanding of physiology. Based on his findings, hydrostatic pressure and oncotic pressure are crucial factors in the movement of intravascular and extravascular fluid. However, new literatures on endothelial glycocalyx, a layer of protective glycoprotein within the vasculature that was first discovered in the 1980s, are reshaping our standard models of Starling's forces. This article examines the nature of the endothelial glycocalyx and why understanding it may change the way we resuscitate patients with sepsis.

Hepatic portal venous gas from nonischemic cause: a case report.

Chen, L. Critical care nursing quarterly 38, (390-2). 10.1097/CNQ.0000000000000085

Point-of-Care Ultrasonography in Emergency and Critical Care Medicine.

Chen, L., & Malek, T. Critical care nursing quarterly 41, (94-101). 10.1097/CNQ.0000000000000190

To stabilize critically ill patients, emergency and critical care medicine providers often require rapid diagnosis and intervention. The demand for a safe, timely diagnostic device, alongside technological innovation, led to the advent of point-of-care ultrasonography (POCUS). POCUS allows the provider to gain invaluable clinical information with a high level of accuracy, leading to better clinical decision-making and improvements in patient safety. We have outlined the history of POCUS adaptation in emergency and critical care medicine and various clinical applications of POCUS described in literature.

Stuck Inside a Cloud: Optimizing Sedation to Reduce ICU-Associated Delirium in Geriatric Patients.

Chen, L., & Lim, F. A. Critical care nursing quarterly 38, (245-52). 10.1097/CNQ.0000000000000067

Elderly population account for more than 50% of all intensive care admissions, and during their stay, up to 87% of them suffer from delirium. There is a large body of evidence demonstrating increased mortality and worse cognitive function for elderly patients who become delirious during their intensive care unit stay. Although the cause of delirium is multifactorial, inappropriate and outdated sedation methods are preventable causes. We review the current best evidences and provide what we believe are the best sedation strategies that are in line with the Society of Critical Care Medicine's Pain, Agitation and Delirium best practice guideline to reduce the incidence of intensive care unit-associated delirium.