Laura Jelliffe-Pawlowski

Faculty

Jelliffe-Pawlowski Headsot

Laura Jelliffe-Pawlowski

PhD MS

Florence S. and William H. Downs Professor in Nursing Research
Senior Associate Dean of Research

1 212 998 9020

433 First Ave
New York, NY 10010
United States

Laura Jelliffe-Pawlowski's additional information

Laura Jelliffe-Pawlowski, PhD, MS, is a Professor at NYU Rory Meyers College of Nursing. Prof. Jelliffe-Pawlowski’s research interests focus on understanding and addressing the drivers and consequences of adverse pregnancy outcomes with a special emphasis on preterm birth and associated racial/ethnic and socioeconomic inequities. Her work is highly transdisciplinary and looks at the interplay of biomolecular, social, and policy factors in observed patterns and outcomes. Her teaching and mentorship activities reflect this transdisciplinary approach with an emphasis on motivating the translation of research findings into action.

Jelliffe-Pawlowski leads a number of statewide, national, and international research efforts funded by the National Institutes of Health, the Bill and Melinda Gates Foundation, the March of Dimes, the State of California, and other entities. These includes, notably, the “Healthy Outcomes of Pregnancy for Everyone (HOPE)” consortium and study which focuses on understanding the experience of pregnant people and their infants pre- and post-COVID 19 pandemic. HOPE examines how biomolecular, social, and community factors affect the well-being and outcomes of mothers and infants and includes enrollment during pregnancy with outcome follow-up to 18-months after birth. Other ongoing projects include, for example, the NIH funded “Prediction Of Maturity, Morbidity, and Mortality in PreTerm Infants (PROMPT)”, study which focuses on examining the metabolic profiles of newborns with early preterm birth and associated outcomes, the “Transforming Health and Reducing PerInatal Anxiety through Virtual Engagement (THRIVE)”, randomized control trial (RCT), funded by the State of California which examines whether digital cognitive behavior therapy delivered by mobile app can assist in reducing anxiety symptoms in pregnant people and also examines participant acceptability of the application. Ongoing efforts also include leading the “California Prediction of Poor Outcomes of Pregnancy (CPPOP)” cohort study which focuses on investigating multi-omic drivers of preterm birth. The study interrogates biomolecular signals associated with preterm birth and includes full genome sequencing and mid-pregnancy biomolecular signaling related to metabolic, immune, stress, and placental function in hundreds of pregnancies with and without preterm birth.

Prior to her joining NYU Rory Meyers College of Nursing, Jelliffe-Pawlowski was a Professor of Epidemiology & Biostatistics, Chief of the Division of Lifecourse Epidemiology, a Professor in the Institute of Global Health Sciences, and Director of Discovery and Precision Health for the UCSF California Preterm Birth Initiative in the University of California San Francisco (UCSF) School of Medicine. She has a lifetime appointment as an Emeritus Professor of Epidemiology & Biostatistics in the UCSF School of Medicine and continues to work closely with the new Center for Birth Equity at UCSF. Prior to her appointment at UCSF, she was a leader at the Genetic Disease Screening Program within the California Department of Public Health.

Jelliffe-Pawlowski efforts have been highlighted in numerous academic and lay articles including in the New York Times, in WIRED Magazine, in the Atlantic, on CNN, and on MSNBC. In 2023, she was recognized by Forbes Magazine as one of the top 50 over 50 Innovators in the United States. She is also a Phase I and Phase II Bill and Melinda Gates Foundation Grand Challenges awardee for her work in the United States and Uganda which focused on the development and validation of newborn metabolic profile as a novel measure of gestational age in infants.

PhD in Human Development, University of California Davis
MS in Child Development, University of California Davis
BA in Psychology, University of California Los Angeles
Preterm Birth

Faculty Honors Awards

Forbes 50 over 50 awardee in Innovation (2023)
Delegate, African Academy of Sciences (2016)
Awardee, Bill and Melinda Bates Foundation, Gates Grand Challenges Phase I and II
Governor Brown Appointee for the California Department of Public Health, Interagency Coordinating Council on Early Intervention

Publications

Assessing Racial/Ethnic Variation and Trends in Vaginal Birth after Cesarean in California: A Retrospective Cohort Study Using Linked Birth Certificate and Hospital Discharge Records

Jelliffe-Pawlowski, L., Rubashkin, N., Teal, E. N. N., Baer, R. J., Vedam, S., Kuppermann, M., Lanouette, G., Jelliffe-Pawlowski, L. L., & Rosenstein, M. G. (2026). In American journal of perinatology (Vols. 43, Issues 2, pp. 145-154).
Abstract
Abstract
Increasing the vaginal birth after cesarean (VBAC) rate to 18% was a Healthy People 2020 goal. Detailed data on racial/ethnic differences in VBAC rates is lacking and can inform efforts to equitably increase VBAC rates. This study aimed to assess racial/ethnic variation in VBAC rates and to describe group trends in VBAC rates in California between 2011 and 2021.This retrospective cohort study used a database of birth certificates linked to hospital discharge records. We analyzed singleton, term live births among people who had a history of at least one prior cesarean birth, no identified contraindications to a vaginal birth, and self-identified their racial/ethnic group as Hispanic or non-Hispanic (American Indian-Alaskan Native (AIAN), Asian, Black, Hawaiian/Pacific Islander, or white). VBAC births were identified from birth certificate records. Differences between VBAC rates were assessed using univariable and multivariable Poisson log-linear regression while adjusting for potential confounders.A total of 607,808 birthing people were included (2,234 AIAN, 84,899 Asian, 34,217 Black, 2,559 Hawaiian/Pacific Islander, 334,116 Hispanic, 149,783 white). Over the study period, Hawaiian/Pacific Islander birthing people had the highest average VBAC rate at 11.5% (AIAN, 6.5%; Asian, 8.8%; Black, 8.0%; Hispanic, 7.4%; white, 9.5%). In adjusted models, Black (aRR = 1.06, 95% CI: 1.01-1.11) and Hawaiian/Pacific Islander (aRR = 1.43, 95% CI: 1.27-1.61) birthing people were more likely to have a VBAC compared with white birthing people, while Hispanic birthing people were less likely (aRR = 0.96, 95% CI: 0.93-0.98). VBAC rates increased significantly ( 

CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic and tolerogenic properties

Jelliffe-Pawlowski, L., Dwyer, L. R., DeRogatis, A. M., Clancy, S., Gouirand, V., Chien, C., Rogers, E. E., Oltman, S. P., Jelliffe-Pawlowski, L. L., van den Broek, T., van Wijk, F., Lynch, S. V., Rutishauser, R. L., Wagner, A., Combes, A. J., & Scharschmidt, T. C. (2026). In The Journal of clinical investigation.
Abstract
Abstract
Neonatal life is marked by rapid antigen exposure, necessitating establishment of peripheral immune tolerance via conversion of naïve CD4+ T cells into regulatory T cells (Tregs). Here, we demonstrated heightened capacity for FOXP3 expression and tolerogenic function among cord blood versus adult blood naive CD4+ T cells and showed that this is linked to their unique metabolic profile and elevated expression of the NADase, CD38. Early-life naïve CD4+ T cells demonstrated a metabolic preference for glycolysis, which directly facilitated their differentiation trajectory. We revealed an age-dependent gradient in CD38 levels on naïve CD4+ T cells and showed that high CD38 expression contributes to both the glycolytic state and tolerogenic potential of neonatal CD4+ T cells, effects that were mediated at least in part via the NAD-dependent deacetylase SIRT1. Thus, the early-life window for peripheral tolerance in humans is critically enabled by the immunometabolic state of the naïve CD4+ compartment.

A Roadmap for Accelerating Research in Intellectual and Developmental Disabilities Using PCORnet®

Jelliffe-Pawlowski, L., Franklin, M. S. S., Dolor, R. J., Hendren, S., Jelliffe-Pawlowski, L., Wiley, S., Myers, S. M., Quiñones, A., Nowell, K., Kanne, S. M., Kramer, J. M., Thompson, B., Thomas, E., Bello, J., Pham, H. M. H., & Maslow, G. R. (2026). In Medical care (Vols. 64, Issue 2S Suppl 3, pp. S301-S313).
Abstract
Abstract
This project sought to (1) identify critical gaps in knowledge of intellectual/developmental disabilities (IDD) clinical care and accelerate research by identifying a set of high-priority patient-centered comparative clinical effectiveness research (CER) questions that may be answered using PCORnet and (2) provide recommendations to advance CER for people with IDD (PwIDD).

Assessing Racial/Ethnic Variation and Trends in Vaginal Birth after Cesarean in California : A Retrospective Cohort Study Using Linked Birth Certificate and Hospital Discharge Records

Rubashkin, N., Teal, E. N., Baer, R. J., Vedam, S., Kuppermann, M., Lanouette, G., Jelliffe-Pawlowski, L., & Rosenstein, M. G. (2025). In American Journal of Perinatology. 10.1055/a-2593-0555
Abstract
Abstract
Objective Increasing the vaginal birth after cesarean (VBAC) rate to 18% was a Healthy People 2020 goal. Detailed data on racial/ethnic differences in VBAC rates is lacking and can inform efforts to equitably increase VBAC rates. This study aimed to assess racial/ethnic variation in VBAC rates and to describe group trends in VBAC rates in California between 2011 and 2021. Study Design This retrospective cohort study used a database of birth certificates linked to hospital discharge records. We analyzed singleton, term live births among people who had a history of at least one prior cesarean birth, no identified contraindications to a vaginal birth, and self-identified their racial/ethnic group as Hispanic or non-Hispanic (American Indian-Alaskan Native (AIAN), Asian, Black, Hawaiian/Pacific Islander, or white). VBAC births were identified from birth certificate records. Differences between VBAC rates were assessed using univariable and multivariable Poisson log-linear regression while adjusting for potential confounders. Results A total of 607,808 birthing people were included (2,234 AIAN, 84,899 Asian, 34,217 Black, 2,559 Hawaiian/Pacific Islander, 334,116 Hispanic, 149,783 white). Over the study period, Hawaiian/Pacific Islander birthing people had the highest average VBAC rate at 11.5% (AIAN, 6.5%; Asian, 8.8%; Black, 8.0%; Hispanic, 7.4%; white, 9.5%). In adjusted models, Black (aRR = 1.06, 95% CI: 1.01-1.11) and Hawaiian/Pacific Islander (aRR = 1.43, 95% CI: 1.27-1.61) birthing people were more likely to have a VBAC compared with white birthing people, while Hispanic birthing people were less likely (aRR = 0.96, 95% CI: 0.93-0.98). VBAC rates increased significantly (p < 0.001) over time for all groups except AIAN birthing people. Conclusion VBAC rates increased for most racial/ethnic groups in California. With the exception of the Hawaiian/Pacific Islander group, there were small and likely not clinically significant differences in the chances for a VBAC across groups. No group in California met the Healthy People 2020 goal VBAC rate of 18%. Key Points VBAC rates increased for most racial/ethnic groups. The VBAC rate for AIAN birthing people did not increase. No group met the Healthy People 2020 goal VBAC rate of 18%.

The Association Between Longer Maternal Leukocyte Telomere Length in the Immediate Postpartum Period and Preterm Birth in a Predominately Latina Cohort of Mothers

Jelliffe-Pawlowski, L., Dutson, U., Lin, J., Jelliffe-Pawlowski, L. L., Coleman-Phox, K., Rand, L., & Wojcicki, J. M. (2025). In Maternal and child health journal.
Abstract
Abstract
We investigated the association between maternal leukocyte telomere length (LTL) in the immediate postpartum period and moderate to late preterm birth (32- 

The Association Between Longer Maternal Leukocyte Telomere Length in the Immediate Postpartum Period and Preterm Birth in a Predominately Latina Cohort of Mothers

Dutson, U., Lin, J., Jelliffe-Pawlowski, L., Coleman-Phox, K., Rand, L., & Wojcicki, J. M. (2025). In Maternal and Child Health Journal. 10.1007/s10995-025-04056-z
Abstract
Abstract
Objectives: We investigated the association between maternal leukocyte telomere length (LTL) in the immediate postpartum period and moderate to late preterm birth (32– < 37 weeks) among Latinas, a population at high risk for preterm birth. Methods: Maternal LTL was measured using quantitative polymerase chain reaction at delivery in a prospective San Francisco primarily Latina birth cohort. Logistic regression models were used to investigate the association between postpartum maternal LTL and preterm birth. Maternal LTL was analyzed as a continuous predictor. Results: Out of 194 participants, 23 (11.9%) had preterm delivery. Longer postnatal maternal LTL was associated with preterm birth (crude OR 4.68; 95% confidence interval (CI) 1.07, 20.6, p = 0.039; adjusted OR 12.8, 95% CI 1.83, 99.9, p = 0.010). Age-stratified analysis showed that being under 35 years increased the effect size of the association between maternal LTL and preterm birth (adjusted OR 32.5, 95% CI 2.58, 597, p < 0.01). Conclusions for Practice: Latina mothers with moderate to late preterm infants had longer LTL in the immediate postpartum period compared to those with term infants. This association was stronger for mothers under the age of 35 years. LTL may serve as a biomarker to better understand the pathophysiology and risk of preterm birth and could inform targeted interventions for prevention and early detection. Future studies are needed to understand physiological changes in maternal LTL from the prenatal to postnatal period in relation to birth outcomes.

CD38 expression by neonatal human naïve CD4 T cells shapes their distinct metabolic state and tolerogenic potential

Jelliffe-Pawlowski, L., Dwyer, L. R., DeRogatis, A. M., Clancy, S., Gouirand, V., Chien, C., Rogers, E. E., Oltman, S. P., Jelliffe-Pawlowski, L. L., Lynch, S. V., Rutishauser, R. L., Wagner, A., Combes, A. J., & Scharschmidt, T. C. (2025). In bioRxiv : the preprint server for biology.
Abstract
Abstract
Neonatal life is marked by rapid antigen exposure, necessitating establishment of peripheral immune tolerance via conversion of naïve CD4 T cells into regulatory T cells (Tregs). Here, we demonstrate heighted capacity for FOXP3 expression and tolerogenic function among cord blood versus adult blood naive CD4 T cells and that this is linked to their unique metabolic profile and elevated expression of the NADase, CD38. Early life naïve CD4 T cells demonstrate a metabolic preference for glycolysis, which directly facilitates their differentiation trajectory. We reveal an age-dependent gradient in CD38 levels on naïve CD4 T cells and show that high CD38 expression contributes to both the glycolytic state and tolerogenic potential of neonatal CD4 T cells, effects that are mediated at least in part via the NAD-dependent deacetylase SIRT1. Thus, the early life window for peripheral tolerance in humans is critically enabled by the immunometabolic state of the naïve CD4 compartment.

Clinical risk factors and adverse perinatal outcomes among U.S. and African-born Black women in California

Jelliffe-Pawlowski, L., McKenzie-Sampson, S., Baer, R. J., Costello, J., Karasek, D., Torres, J. M., Riddell, C. A., Jelliffe-Pawlowski, L. L., & Blebu, B. E. (2025). In Journal of perinatology : official journal of the California Perinatal Association (Vols. 45, Issues 12, pp. 1715-1721).
Abstract
Abstract
Examine the association between clinical risk factors for preterm birth (PTB) and small for gestational age delivery (SGA) among United States (US)- and African-born Black women.

Clinical risk factors and adverse perinatal outcomes among U.S. and African-born Black women in California

McKenzie-Sampson, S., Baer, R. J., Costello, J., Karasek, D., Torres, J. M., Riddell, C. A., Jelliffe-Pawlowski, L., & Blebu, B. E. (2025). In Journal of Perinatology. 10.1038/s41372-025-02361-7
Abstract
Abstract
Objective: Examine the association between clinical risk factors for preterm birth (PTB) and small for gestational age delivery (SGA) among United States (US)- and African-born Black women. Study design: Population-based study of singleton births to 171,051 US- and 19,269 African-born women in California (2011–2020). Associations between PTB and SGA with 14 clinical risk factors were examined. Adjusted Poisson regression models estimated the association between each clinical factor and the outcomes, while assessing interaction by nativity. Results: The prevalence of PTB, SGA, and clinical factors was greater among US-born Black women, with the exception of gestational diabetes. On average, the risk of PTB and SGA among women with each clinical risk factor was significantly higher for African- compared to US-born Black women. Conclusions: Clinical risk factors were higher among US-born women, however associations between each factor and adverse perinatal outcomes were stronger for African-born women.

Digital cognitive behavior therapy to reduce perinatal anxiety symptoms: perceptions of implementation barriers and facilitators among providers serving historically marginalized communities

Jelliffe-Pawlowski, L., Blebu, B., Ponting, C., Blackman, K. C. A., Baer, R. J., Felder, J., Oltman, S. P., Jelliffe-Pawlowski, L., & Tabb, K. M. (2025). In Translational behavioral medicine (Vols. 15, Issue 1).
Abstract
Abstract
Perinatal anxiety is prevalent, particularly among historically marginalized groups who face barriers to accessing interventions like cognitive behavioral therapy (CBT). While digital CBT adaptations for this population show promise, research on implementation remains limited.

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