Ashleigh M. Holmes

Faculty

Ashleigh Holmes Headshot

Ashleigh M. Holmes

PhD MSN RN AGPCNP-BC

Clinical Assistant Professor

1 212 992 5945

433 FIRST AVENUE
NEW YORK, NY 10010
United States

Ashleigh Holmes, PhD, MSN, RN, AGPCNP-BC, is a clinical assistant professor at NYU Rory Meyers College of Nursing. Her research interests include chronic pain and mental health in older adults, data science methodologies, and models of care. She is passionate about the older adult population and enjoys teaching about the art and science of managing complex chronic conditions, palliative care needs, and geropharmacology.
 

Prior to joining the faculty at NYU Meyers, Holmes was a preceptor and adjunct lecturer in the Family Nurse Practitioner program at the State University of New York Polytechnic Institute. Certified as an adult-gerontology primary care nurse practitioner, she worked in primary care for several years before transitioning to subacute rehabilitation.
 

Holmes earned her BSN from the University of Pittsburgh in 2016 and her MSN and palliative care minor from the University of Pennsylvania in 2017. She completed her PhD in nursing through the University at Buffalo in 2025. Her doctoral research explored the longitudinal trajectories of psychosocial phenotypes in older adults with pain.

PhD, Nursing – University at Buffalo
MS, Adult-Gerontology Primary Care Nurse Practitioner – University of Pennsylvania
BS, Nursing – University of Pittsburgh

Gerontology
Primary care
Pain Medicine

American Association of Nurse Practitioners
Eastern Nursing Research Society
Gerontological Society of America

School of Nursing 11th Annual Research Day Ellen Volpe Memorial Reward- PhD research poster (2024)
School of Nursing 10th Annual Research Day Poster Awards First Place Prize for PhD students (2023)
School of Nursing 9th Annual Research Day Poster Awards First Place Prize for PhD Students (2022)
Keeper of the Light, University of Pittsburgh School of Nursing (2016)
Stephanie Mucha Scholar, University at Buffalo School of Nursing

The Association Between Caregiving Burden, the Caregiving Relationship, and Caregiver Health

Holmes, A. M., de Rosa, C. B., Holmes, A., Wang, W., & Chang, Y.-P. P. (2025). In Journal of gerontological nursing (Vols. 51, Issues 5, pp. 27-34).
Abstract
Abstract
To determine the mediating effects of the quality of family caregivers' relationships with their older adult care recipients on the association between care-giver burden and caregivers' mental health and perceived general health.

Psychosocial Phenotypes of Older Adults With Pain and Their Associated Clinical Outcomes

Holmes, A. M., Holmes, A., Wang, W., & Chang, Y.-P. P. (2025). In Journal of applied gerontology : the official journal of the Southern Gerontological Society (Vols. 44, Issues 4, pp. 600-613).
Abstract
Abstract
A comprehensive understanding of the patterns of psychosocial characteristics in older adults with pain is needed. Our objectives were to (1) identify psychosocial phenotypes (comprising depression, anxiety, affect, self-realization, resilience, and social participation) among older adults with pain and (2) compare pain characteristics, physical health, and cognition among the identified phenotypes. Using cross-sectional 2021 data from the National Health and Aging Trends Study, we performed latent class analysis to identify four psychosocial phenotypes of older adults with pain ( = 1903): Favorable (best psychosocial characteristics, 67.7%), Adverse (worst psychosocial characteristics, 4.9%), Intermediate (moderate scores on psychosocial variables, 12.6%), and Compensated (moderate scores with relatively high self-realization and resilience, 14.9%). Phenotypes with less psychosocial adversity had generally better clinical outcomes. Future research should explore precision pain management interventions in older adults based on their psychosocial phenotypes, longitudinal trajectories of phenotypes, and technology-based, point-of-care clinical insights for pain management.

Non-pharmacological management of neuropathic pain in older adults: a systematic review

Holmes, A. M., Holmes, A., & Chang, Y.-P. P. (2024). In Pain medicine (Malden, Mass.) (Vols. 25, Issue 1, pp. 47-56).
Abstract
Abstract
Neuropathic pain encompasses multiple diagnoses with detrimental impacts on quality of life and overall health. In older adults, pharmacological management is limited by adverse effects and drug interactions, while surgical management involves perioperative risk. Prior reviews addressing non-pharmacological interventions for neuropathic pain have not focused on this demographic. Therefore, this systematic review synthesizes the evidence regarding the effectiveness of non-pharmacological interventions in reducing neuropathic pain severity in older adults.

Psychosocial Characteristics by Pain Presence and Limitations Among Older Adults

Holmes, A. M., Holmes, A., Wang, W., & Chang, Y.-P. P. (2024). In Journal of gerontological nursing (Vols. 50, Issues 7, pp. 27-34).
Abstract
Abstract
To compare psychosocial outcomes of older adults according to pain experience.

Effect of mental health collaborative care models on primary care provider outcomes: an integrative review

Holmes, A. M., Holmes, A., & Chang, Y.-P. P. (2022). In Family practice (Vols. 39, Issues 5, pp. 964-970).
Abstract
Abstract
Collaborative care models (CCMs) have robust research evidence in improving mental health outcomes for diverse patient populations with complex health care needs. However, the impact of CCMs on primary care provider (PCP) outcomes are not well described.