Project

This study identifies a novel area for exploration and aligns well with the NINR Strategic Plan, calling for studies on symptom science with a focus on Promoting Personalized Medicine, by understanding the mechanisms underlying the symptom of fatigue through symptom science research. Cancer-related fatigue is one of the most frequently reported symptoms distressing men while receiving radiotherapy for prostate cancer. Questions remain regarding the etiology of fatigue during radiation treatment, as well as about how mTOR pathway dysregulation may lead to debilitating fatigue. Exploring the relationship of changes in mTOR signaling pathway at the levels of gene expression, epigenetic regulation, and protein expression will provide initial information about potential mechanisms behind the development of cancer-related fatigue, and may provide molecular targets for individualized interventions, leading to more effective management of fatigue in this population.