Niyati Parekh's additional information
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Prof. Niyati Parekh’s research and teaching are motivated by a deep commitment to reduce nutrition-related disease outcomes in at-risk groups. In pursuit of this goal, as a nutritional epidemiologist, she has developed a robust research portfolio that examines the intersection of biological and behavioral factors of non-communicable diseases in US populations. The overarching theme of her research program is to examine the role of nutrition and diet-related factors in the etiology of non-communicable diseases, with a particular focus on obesity, metabolic dysregulation and cancer. Her multidisciplinary research integrates the intricacies from four distinct areas of expertise: disease biology, nutritional biochemistry, epidemiology and biostatistics. She has developed a research program with three interconnected areas that are unified under the theme of investigating diet and non-communicable diseases in populations, using epidemiologic methods. The first arm consists of leveraging existing data to identify dietary patterns, dietary quality and food consumption patterns in populations of interest. The second is to identify dietary determinants and biomarkers that predict disease outcomes including obesity, diabetes, cardiovascular disease and cancer. The third arm is to measure diets using novel dietary assessment methods that will contribute to more accurate and multi-dimensional measurement of diet. The three areas of her work complement each other and reveal preventive measures for populations, inform health policy and guide clinical practice. She has 75 peer-reviewed publications and her work has been supported by awards from the American Cancer Society and NIH.
Prof. Parekh holds an MS in Clinical Nutrition from Mumbai University and a PhD in Nutritional Sciences with a minor in Population Health Sciences from the University of Wisconsin-Madison (2005). After completing a 2-year postdoctoral fellowship in Cancer Epidemiology at the Cancer Institute of New Jersey-Rutgers, she joined New York University Steinhardt’s Department of Nutrition, Food Studies and Public Health in January 2008. With doctoral and postdoctoral training in epidemiological methods, she cross-pollinated the fields of nutrition and public health. In 2015, as Associate Professor of Public Health Nutrition, she transitioned to NYU’s newly launched School of Global Public Health (GPH), as Director of the Public Health Nutrition program (until 2019). She also has an affiliated appointment at the Department of Population Health-Grossman School of Medicine.
Her recent honors include being inducted as a New York Academy of Medicine Fellow, and her appointment as Independent Consultant at UNICEF. She has served the American Society for Nutrition as Chair of the Nutritional Epidemiology Research Group. She teaches graduate courses in the New York Campus and at study abroad sites (Mexico, Abu Dhabi and Florence). Graduate courses taught include Global Nutrition, Nutritional Epidemiology, Perspectives in Public Health and Global Cancer Epidemiology for which she has received awards. Prof. Parekh served as the Executive Director of Doctoral Programs at GPH from 2017-2021. In this role, she supported PhD students school-wide, and promoted all aspects of their rigorous research and professional development towards impactful careers. Prof. Parekh was appointed as the Associate Vice Provost of Faculty Initiatives in August 2021 and is responsible for mentoring early career tenure track-faculty.
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PhD, Nutritional Sciences (minor Population Health Sciences), University of Wisconsin-Madison, Madison, WIMS, Foods, Nutrition, and Clinical Dietetics, Mumbai University, IndiaBS, Life Sciences and Biotechnology, Mumbai University, India
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Faculty Honors Awards
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Publications
Healthy diets and the subsequent prevalence of nuclear cataract in women.
Mares, J., Voland, R., Adler, R., Tinker, L., Millen, A., Moeller, S., Blodi, B., Gehrs, K. M., Wallace, R., Parekh, N., Chappell, R., Neuhouser, M., & Sarto, G. E. (2010). JAMA Opthalmology, 128(6), 738-749.Lifestyle, Anthropometric, and Obesity-Related Physiologic Determinants of Insulin-like Growth Factor-1 in the Third National Health and Nutrition Examination Survey (1988-1994)
AbstractParekh, N., Roberts, C. B., Vadiveloo, M., Puvananayagam, T., Albu, J. B., & Lu-Yao, G. L. (2010). Annals of Epidemiology, 20(3), 182-193. 10.1016/j.annepidem.2009.11.008AbstractPurpose: Epidemiologic studies suggest that insulin-like growth factor-1 (IGF-1) is associated with obesity and, more recently, cancer. This study investigates multiple lifestyle, physiologic, and anthropometric determinants of circulating IGF-1 concentrations. Methods: Nationally representative data were used from the cross-sectional Third National Health and Nutrition Examination (NHANES III, 1988-1994) survey, which measured IGF-1 concentrations in blood, from a subsample of participants who were examined in the morning. After exclusion of persons with missing data, 6,058 men and women 20 years of age or older were included in the study. Results: The mean IGF-1 concentrations were 260 ng/mL in the entire population and were higher among men as compared with women (278.8 vs. 241.3 ng/mL; p < 0.0001). IGF-1 decreased with increasing age (p < 0.0001), body mass index (p < 0.0001), and waist circumference (p < 0.0001). Individuals with metabolic syndrome had lower IGF-1 concentrations after adjustment for covariates (p = 0.0008). IGF-1 was inversely associated with increasing number of metabolic syndrome abnormalities (p = 0.0008). All associations were stronger among women compared with men except across concentrations of glucose. IGF-1 concentrations did not vary by any other lifestyle or physiologic factors. Conclusions: Age, adiposity, hyperglycemia, and metabolic syndrome influenced circulating IGF-1 concentrations. Diet and physical activity had no impact on IGF-1 in this nationally representative population.Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey
AbstractParekh, N., Lin, Y., Hayes, R. B., Albu, J. B., & Lu-Yao, G. L. (2010). Cancer Causes and Control, 21(4), 631-642. 10.1007/s10552-009-9492-yAbstractInsulin and glucose may influence cancer mortality via their proliferative and anti-apoptotic properties. Using longitudinal data from the nationally representative Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994), with an average follow-up of 8.5 years to death, we evaluated markers of glucose and insulin metabolism, with cancer mortality, ascertained using death certificates or the National Death Index. Plasma glucose, insulin, C-peptide, and lipid concentrations were measured. Anthropometrics, lifestyle, medical, and demographic information was obtained during in-person interviews. After adjusting for age, race, sex, smoking status, physical activity, and body mass index, for every 50 mg/dl increase in plasma glucose, there was a 22% increased risk of overall cancer mortality. Insulin resistance was associated with a 41% (95% confidence interval (CI) (1.07-1.87; p = 0.01) increased risk of overall cancer mortality. These associations were stronger after excluding lung cancer deaths for insulin-resistant individuals (HR: 1.67; 95% CI: 1.15-2.42; p = 0.01), specifically among those with lower levels of physical activity (HR: 2.06; 95% CI: 1.4-3.0; p = 0.0001). Similar associations were observed for other blood markers of glucose and insulin, albeit not statistically significant. In conclusion, hyperglycemia and insulin resistance may be 'high-risk' conditions for cancer mortality. Managing these conditions may be effective cancer control tools.Obesity and prostate cancer detection: Insights from three national surveys
AbstractParekh, N., Lin, Y., Dipaola, R. S., Marcella, S., & Lu-Yao, G. (2010). American Journal of Medicine, 123(9), 829-835. 10.1016/j.amjmed.2010.05.011AbstractBackground: Previous studies suggest that obesity is associated with higher prostate cancer progression and mortality despite an association with lower prostate cancer incidence. This study aims to better understand these apparently inconsistent relationships among obese men by combining evidence from 3 nationally representative cross-sectional surveys. Methods: We evaluated relationships between obesity and 1) testosterone concentrations in the Third National Health and Nutrition Examination Survey (NHANES III; n = 845); 2) prostate-specific antigen (PSA) in NHANES 2001-2004 (n = 2458); and 3) prostate biopsy rates in the National Health Interview Survey (NHIS 2000; n = 4789) population. Mean testosterone, PSA concentrations, and biopsy rates were computed for Body Mass Index (BMI) categories. Results: Testosterone concentrations were inversely associated with obesity (P-trend <.0001) in NHANES III. In NHANES 2001-2004, obese (BMI >35) versus lean (BMI <25) men were less likely to have PSA concentrations that reached the biopsy threshold of >4 ng/mL (3% vs 8%; P <.0001). Among NHIS participants, all BMI groups had similar rates of PSA testing (P = .24). However, among men who had PSA tests, 11% of men with BMI >30 versus 16% with BMI <25, achieved a PSA threshold of 4 ng/mL; P = .01. Furthermore, biopsy rates were lower among men with BMI >30 versus BMI <25 in NHIS participants (4.6% vs 5.8%; P = .05). Conclusions: Obesity was associated with lower PSA-driven biopsy rates. These data support further studies to test the hypothesis that obesity affects prostate cancer detection independent of prostate cancer risk by decreasing the PSA-driven biopsy rates.Protective role of vitamin D against age-related macular degeneration: A hypothesis
AbstractParekh, N. (2010). Topics in Clinical Nutrition, 25(4), 290-301. 10.1097/TIN.0b013e3181fabac1AbstractAge-related macular degeneration (AMD) is the leading cause of blindness among Americans. Local inflammation is implied in the pathophysiology of AMD that may cause photoreceptor destruction and blindness. Vitamin D may prevent AMD progression via its anti-inflammatory and antiangiogenic properties. Scientific evidence is discussed for the associations of vitamin D (serum, diet, and sunlight) and AMD. Evidence suggests inverse associations between serum vitamin D and its sources (specifically fish), and AMD. Associations with sunlight, hypothesized to increase risk for AMD, have been inconsistent possibly due to protection from vitamin D. Vitamin D may be a new protective factor against AMD.Suspected nonalcoholic fatty liver disease is not associated with vitamin D status in adolescents after adjustment for obesity
AbstractKatz, K., Brar, P. C., Parekh, N., Liu, Y. H., & Weitzman, M. (2010). Journal of Obesity, 2010. 10.1155/2010/496829AbstractThis study investigated a potential independent association between hypovitaminosis D and suspected nonalcoholic fatty liver disease (NAFLD) in a nationally representative sample of the US adolescents. Data from 1630 subjects 12-19 years of age were examined using the National Health and Nutrition Examination Survey, 2001-2004. The vitamin D status of subjects was categorized into quartiles of serum 25-hydroxyvitamin D. Subjects with serum ALT>30 U/L were classified as having suspected NAFLD. Data regarding age, sex, race, BMI, and poverty level were also analyzed in bivariate and multivariate analyses using SAS and SUDAAN software. Suspected NAFLD was identified in 12.1% of adolescents in the lowest quartile compared to 6.9% of adolescents in the second quartile, 8.0% in the third quartile, and 13.17% in the highest quartile of serum 25(OH)D concentrations (P=.05). In analyses utilizing vitamin D as a continuous variable, no independent association was found between Vitamin D levels and rates of elevated ALT levels. In multivariate analyses, higher risks for suspected NAFLD were observed in males and overweight adolescents; however, vitamin D status was not found to be independently associated with suspected NAFLD after adjusting for obesity.Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): An ancillary study of the women's health initiative
AbstractParekh, N., Voland, R. P., Moeller, S. M., Blodi, B. A., Ritenbaugh, C., Chappell, R. J., Wallace, R. B., & Mares, J. A. (2009). Archives of Ophthalmology, 127(11), 1483-1493. 10.1001/archophthalmol.2009.130AbstractObjective: To evaluate the relationships between the amount and type of dietary fat and intermediate age-related macular degeneration (AMD). Design: Women aged 50 to 79 years with high and low lutein intake from 3 sites of the Women's Health Initiative Observational Study were recruited into the Carotenoids in Age-Related Eye Disease Study. Fat intake from 1994 through 1998 was estimated using food frequency questionnaires, and AMD was assessed photographically from 2001 through 2004. Results: Intakes of ω-6 and ω-3 polyunsaturated fatty acids, which were highly correlated (r=0.8), were associated with approximately 2-fold higher prevalence of intermediate AMD in high vs low quintiles. However, monounsaturated fatty acid intake was associated with lower prevalence. Age interactions were often observed. In women younger than 75 years (n=1325), total fat and saturated fatty acid intakes were associated with increased prevalence of AMD (multivariate adjusted odds ratios [95% confidence interval] for intermediate AMD, 1.7 [1.0-2.7] for quintile 5 vs quintile 1 for total fat [P=.10 for trend] and 1.6 [0.7-3.6] for saturated fatty acids [P=.23 for trend]). The associations were reversed in older women. Conclusions: These results support a growing body of evidence suggesting that diets high in several types of fat may contribute to the risk of intermediate AMD and that diets high in monounsaturated fatty acids may be protective.Obesity, Insulin Resistance, and Cancer Prognosis: Implications for Practice for Providing Care among Cancer Survivors
Parekh, N., Okada, T., & Lu-Yao, G. L. (2009). Journal of the American Dietetic Association, 109(8), 1346-1353. 10.1016/j.jada.2009.05.001Vegetables intake as a preventative measure against type-2 diabetes and cancer
Parekh, N., & Fitzgerald, N. (2009). In Fruit and vegetable consumption and health (1–, pp. 81-99). Nova Science Publishers, Inc.Zinc and cognitive development in children: Perspectives from international studies
AbstractBlack, J. L., Piñero, D. J., & Parekh, N. (2009). Topics in Clinical Nutrition, 24(2), 130-138. 10.1097/TIN.0b013e3181a6b947AbstractSince 1980, at least 9 studies have assessed the potential associations between zinc supplementation and cognitive development in human infants and children. This article provides a brief review of the literature on the roles of zinc and its proposed associations with cognition. At present, the body of evidence is insufficient to warrant recommending routine zinc supplementation to enhance cognitive performance among children. In the United States and internationally, there are few available data on zinc status or deficiency rates in children and further study is necessary to assess the efficacy of zinc supplementation, alone or in combination with other nutrients, for improving cognitive outcomes.