Xiang Qi

Faculty

Xiang Qi headshot

Xiang Qi

PhD RN

Assistant Professor

1 212 992 5797

433 First Ave
New York, NY 10010
United States

Xiang Qi, PhD, RN, is a tenure-track Assistant Professor at NYU Rory Meyers College of Nursing. His research sits at the intersection of gerontology, social epidemiology & psychiatry, and geriatric nursing. He conducts interdisciplinary research focusing on social disparities of healthy aging and longevity that crosscuts a range of areas in social isolation & loneliness, immigration, and socioeconomic status. The goal of Qi’s work is to reduce health disparities in Alzheimer’s disease and related dementia in the US and globally. Qi is an expert in data science and quantitative methodology, including machine learning, multilevel modeling, and causal inference, and has extensive experience working with large dataset analyses as well as analyzing electronic health records to understand the social determinants of health and health disparities.

Qi is the Principal Investigator on NIH-funded projects investigating the heterogeneity in cognitive health and the disparities in cardiometabolic diseases and mental health across Asian American ethnic groups. Prior to joining the faculty at NYU Meyers, he served as a Research Scientist on the NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers project (P50MD017356) at the Rutgers-NYU Center for Asian Health Promotion and Equity. He also held positions as a Statistical Analyst on the NIH-funded projects to elucidate the neurobiological pathways on the associations between poor oral health and dementia.

Among his many honors, Qi has received the Douglas Holmes Emerging Scholar Paper Award, the ESPO Best Poster Award, and the Minority Issues in Gerontology Student Poster Award, from the Gerontological Society of America. He has also been recognized with the Rising Star Award, Distinguished Alumni Award, and the 2022-2023 Outstanding PhD Dissertation Award from NYU Meyers.

Additionally, Qi has received the FIRE Doctoral Student Research Leadership Award from the New York Academy of Medicine. His work has been featured in numerous media outlets, including U.S. News & World Reports, Yahoo!, Cable News Network (CNN), Science News, PsyPost, Daily Nurse, Dental Tribute, National Institute of Aging, Dentistry Today, and Neuroscience News. Qi’s research on the associations between social isolation, loneliness, and cognitive health has garnered significant attention and recognition.

Qi earned his PhD from New York University. He completed his Bachelor of Science at Fudan University in Shanghai, China, which included an exchange program at the Department of Neurobiology, Physiology & Behavior, University of California, Davis.

PhD, Nursing Research and Theory Development, New York University
Exchange Program, Neurobiology, Physiology & Behavior, University of California, Davis
BS, Fudan University

Gerontology
Oral-systemic health
Immigrants
Mental health
Underserved populations
Community/population health

Alzheimer’s Association International Society
New York Academy of Medicine
Sigma Theta Tau Nursing Honor Society
Gerontological Society of American
Eastern Nursing Research Society

Minority Issues in Gerontology Student Poster Award, Gerontological Society of American (2023)
2022-2023 Outstanding PhD Dissertation Award, NYU Rory Meyers College of Nursing (2023)
The Emerging Scholar and Professional Organization – Carol Schutz Student Travel Award, Gerontological Society of American (2022)
Minority Issues in Gerontology Student Poster Award, Gerontological Society of American (2022)
Douglas Holmes Emerging Scholar Paper Award, Gerontological Society of American (2022)
The Emerging Scholar and Professional Organization – Best Poster Award, Gerontological Society of American (2022)
FIRE Doctoral Student Research Leadership Award, New York Academy of Medicine (2022)
Student Registration Award, Gerontological Society of American (2021)
Excellent Graduate of Shanghai, Shanghai Municipal Education Commission (2019)
Research and Innovation Award, Fudan University, Fudan University, Shanghai, China (2018)
National Undergraduate Scholarship, Ministry of Education of China (2018)National Undergraduate Scholarship, Ministry of Education of China (2018)
Overseas Exchange Outstanding Student Scholarship, Fudan University, China (2017)
The First Prize Scholarship, Fudan University, China (2016)
Excellent Student Leader, Fudan University, China (2015)

The informal discussion of advance care planning among Chinese older adults: Do education and social media use matter?

Pei, Y., Qi, X., Zhu, Z., Zhang, W., Tsay, R. M., & Wu, B. (2024). Geriatric Nursing, 55, 1-5. 10.1016/j.gerinurse.2023.10.023
Abstract
Abstract
This study aimed to examine and compare the associations between education, social media use, and advance care planning (ACP) discussion among Chinese older adults in mainland China (Wuhan), Taiwan (Taichung), and the United States (Honolulu). Community-dwelling older adults (≥ 55) were recruited from 2017 to 2018. The ACP discussion rate in Wuhan, Taichung, and Honolulu were 15.2 %, 19.2 %, and 31.3 %, respectively. Logistic regression models revealed that education was positively associated with ACP discussion in Taichung and Honolulu. Social media use was positively associated with ACP discussions in Wuhan and Honolulu, and it attenuated the association between education and ACP discussion in Honolulu. The present study contributes to previous studies by comparing the associations between education, social media use, and ACP discussion in different settings within the same ethnicity. Policy and practice implications were also discussed.

Age and Mental Health Symptoms among Chinese Persons with HIV: The Mediating and Moderating Role of Perceived Discrimination

Han, S., Pei, Y., Wang, J., Hu, Y., Zhu, Z., Qi, X., Yang, Z., & Wu, B. (2023). Journal of the Association of Nurses in AIDS Care, 34(1), 105-112. 10.1097/JNC.0000000000000373
Abstract
Abstract
The association between age and mental health symptoms among persons with HIV (PWH) is inconsistent, and little is known about the mediators and moderators of this association. This study aimed to examine the association between age and mental health symptoms, as well as the mediators and moderators of perceived discrimination. Data were from 1,304 PWH who completed a cross-sectional survey in five areas of China. Multiple linear regressions showed that younger age was significantly associated with more severe mental health symptoms and that perceived discrimination moderated this relationship. The Sobel test showed that perceived discrimination also mediated the association between age and mental health symptoms. Our study indicates that perceived discrimination shapes the association between age and mental health symptoms among PWH and highlights the importance of designing age-Tailored mental health intervention strategies for perceived discrimination among young PWH. Interventions addressing discrimination are necessary to help improve mental health, especially for young PWH.

Association Between Types of Loneliness and Risks of Functional Disability in Older Men and Women: A Prospective Analysis

Qi, X., Belsky, D. W., Yang, Y. C., & Wu, B. (2023). American Journal of Geriatric Psychiatry, 31(8), 621-632. 10.1016/j.jagp.2023.02.046
Abstract
Abstract
Objective: To examine the association between types of loneliness (transient, incident, and chronic) and the risk of functional disability. Methods: Data were from the Health and Retirement Study 2006/2008-2016/2018. A total of 7,148 adults aged ≥50 was included. Functional status was measured by activities of daily living (ADL) and instrumental activities of daily living (IADL). Loneliness was assessed using the 3-item UCLA Loneliness Scale. We defined loneliness as no/transient/incident/chronic loneliness based on the pattern and duration of loneliness across 2006/2008 and 2010/2012. We applied multivariate Cox proportional hazard models with the new-onset ADL/IADL disability as outcome. Results: Overall, 69.3% respondents showed no loneliness; while 10.3%, 8.9%, and 11.5% showed transient, incident, and chronic loneliness, respectively. A total of 1,298 (18.16%) and 1,260 (17.63%) functionally normal respondents developed ADL and IADL disability during 36,294 person-years of follow-up, respectively. After adjusting for socio-demographic, behavioral, and health factors, chronic loneliness was associated with higher risks of ADL (hazard ratio [HR] = 1.37, 95% confidence interval [CI] = 1.16–1.63, p <0.001, χ2 = 3.60, degree of freedom [df] = 1) and IADL disability (HR = 1.25, 95% CI = 1.09–1.44, p = 0.002, χ2 = 3.17, df = 1) compared to no loneliness. By contrast, no significant associations between transient loneliness and ADL (HR = 1.17, 95% CI = 0.88–1.57, p = 0.273, χ2 = 1.10, df = 1) or IADL disability (HR = 1.16, 95% CI = 0.97–1.39, p = 0.112, χ2 = 1.59, df = 1) were found. Chronic loneliness was not associated with the risk of IADL disability in men (HR = 1.13, 95% CI = 0.91–1.40, p = 0.263, χ2 = 1.12, df = 1). Conclusion: Chronic loneliness, rather than transient loneliness, is an independent risk factor for functional disability in middle-aged and older adults, especially for women.

Associations of social isolation and loneliness with the onset of insomnia symptoms among middle-aged and older adults in the United States: A population-based cohort study

Qi, X., Malone, S. K., Pei, Y., Zhu, Z., & Wu, B. (2023). Psychiatry Research, 325. 10.1016/j.psychres.2023.115266
Abstract
Abstract
There is an inconsistent conclusion regarding the relationship of social isolation and loneliness with poor sleep. We investigated the associations of social isolation and loneliness with new-onset insomnia symptoms in a nationally-representative sample of 9,430 adults aged ≥50 who were free of any insomnia symptoms/sleep disorders at baseline (wave 12/13) and followed up to 4 years from the Health and Retirement Study. Social isolation was measured by Steptoe's Social Isolation Index. Loneliness was measured by the revised 3-item UCLA-Loneliness Scale. Insomnia symptoms were quantified using the modified Jenkins Sleep Questionnaire. During a mean follow-up of 3.52 years, 1,522 (16.1%) participants developed at least one insomnia symptom. Cox models showed that loneliness was associated with the onset of difficulties initiating or maintaining sleep, early-morning awakening, nonrestorative sleep, and at least one of these symptoms after adjusting for potential covariates; while social isolation was not associated with the onset of difficulties maintaining sleep, early-morning awakening, or at least one insomnia symptom after adjusting for health indicators. These results are consistent in sensitivity analyses and stratified analyses by age, sex, race/ethnicity, and obesity. Public health interventions aimed at fostering close emotional relationships may reduce the burden of poor sleep among middle-aged and older adults.

Diabetes, Edentulism, and Cognitive Decline: A 12-Year Prospective Analysis

Wu, B., Luo, H., Tan, C., Qi, X., Sloan, F. A., Kamer, A. R., Schwartz, M. D., Martinez, M., & Plassman, B. L. (2023). Journal of Dental Research, 102(8), 879-886. 10.1177/00220345231155825
Abstract
Abstract
Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is associated with cognitive impairment and dementia. However, the effect of the co-occurrence of DM and edentulism on cognitive decline is understudied. This 12-y cohort study aimed to assess the effect of the co-occurrence of DM and edentulism on cognitive decline and examine whether the effect differs by age group. Data were drawn from the 2006 to 2018 Health and Retirement Study. The study sample included 5,440 older adults aged 65 to 74 y, 3,300 aged 75 to 84 y, and 1,208 aged 85 y or older. Linear mixed-effect regression was employed to model the rates of cognitive decline stratified by age cohorts. Compared with their counterparts with neither DM nor edentulism at baseline, older adults aged 65 to 74 y (β = −1.12; 95% confidence interval [CI], −1.56 to −0.65; P < 0.001) and those aged 75 to 84 y with both conditions (β = −1.35; 95% CI, −2.09 to −0.61; P < 0.001) had a worse cognitive function. For the rate of cognitive decline, compared to those with neither condition from the same age cohort, older adults aged 65 to 74 y with both conditions declined at a higher rate (β = −0.15; 95% CI, −0.20 to −0.10; P < 0.001). Having DM alone led to an accelerated cognitive decline in older adults aged 65 to 74 y (β = −0.09; 95% CI, −0.13 to −0.05; P < 0.001); having edentulism alone led to an accelerated decline in older adults aged 65 to 74 y (β = −0.13; 95% CI, −0.17 to −0.08; P < 0.001) and older adults aged 75 to 84 (β = −0.10; 95% CI, −0.17 to −0.03; P < 0.01). Our study finds the co-occurrence of DM and edentulism led to a worse cognitive function and a faster cognitive decline in older adults aged 65 to 74 y.

Longitudinal relationships in the psychopathology of depressive symptoms in middle-aged and older adults in China

Zhu, Z., Qi, X., Pei, Y., Wang, J., & Wu, B. (2023). Aging and Mental Health, 27(9), 1692-1701. 10.1080/13607863.2022.2164253
Abstract
Abstract
Objectives: To develop symptom networks and examine the longitudinal relationships of depressive symptoms among middle-aged and older adults in China. Method: This study used three-wave data from the China Health and Retirement Longitudinal Study (2013 (T1), 2015 (T2), and 2018 (T3)). Depressive symptoms were measured by the 10-item Center for Epidemiologic Studies Depression Scale (CES-D). A multilevel vector autoregression model (VAR) was used to identify ten depressive symptoms dynamically interacting with each other over time. Results: A total of 3,558 participants were included in the final analysis. The strongest direct effects were ‘D10: felt fearful’ -> ‘D6: felt everything I did was an effort’ (β = 0.14). ‘D10: felt fearful’ reported the largest value of out-predictability (r = 0.064) and out-strength (r = 0.635). ‘D3: felt depressed’ reported the largest value of in-predictability (r = 0.077) and in-strength (r = 0.545). Substantial heterogeneity in the network may stem from an individual’s sex and place of residence. Conclusions: ‘Felt fearful’ was the strongest predictor compared to the other nine depressive symptoms based on node centrality. Our study suggests that, after understanding the causes of fear, strategies to reduce fear should be incorporated into multimodal interventions for middle-aged and older adults with depressive symptoms.

Perceived social cohesion and depressive symptoms among internal migrants in China: The mediating role of social adaptation

Qu, X., Qi, X., Wu, B., Yu, J., & Zhang, H. (2023). Frontiers in Public Health, 11. 10.3389/fpubh.2023.1096318
Abstract
Abstract
Background: Internal migrants are exposed to higher risks of depressive symptoms due to migration-related stress. It has been recognized that perceived neighborhood social cohesion has direct and indirect associations with depressive symptoms. However, the pathway from perceived social cohesion to internal migrants' depressive symptoms was less discussed. Objectives: To assess mental health disparities among internal migrants. To investigate the association between social cohesion and depressive symptoms among urban-to-urban and rural-to-urban migrants and to examine the mediating role of social adaptation. Methods: Data from the “2017 Urbanization and New Migrant Survey” was used, including 2,584 internal migrants age 18–65 from 10 cities in China. Social cohesion was measured by a six-item modified Community-level Cohesion Scale. Depressive symptoms was measured using the Center for Epidemiological Studies Depression Scale, and social adaptation was assessed by a single-item question of migrants' adaptation to local life. Multivariate linear regression models were used to examine the association between social cohesion and depressive symptoms. Baron and Kenny's mediation tests were conducted to examine the mediating role of social adaptation on the association. All analyses were adjusted using sampling weights to account for this survey's sampling design. Results: Rural-to-urban migrants were found to have more clinically significant depressive symptoms, lower perceived social cohesion, and fair or low social adaptation than urban-to-urban migrants (all p < 0.001). Being rural-to-urban migrants as compared with urban-to-urban migrants [Odds Ratio (OR) = 1.46, 95% Confidence Interval (CI) = 1.456, 1.461, p < 0.001], had lower perceived social cohesion (OR = 1.46, 95% CI = 1.458, 1.463, p < 0.001), and poorer social adaptation (OR = 1.94, 95% CI = 1.932, 1.941, p < 0.001), are associated with higher odds of having clinically significant depressive symptoms. Social adaptation partially mediated the association between social cohesion and depressive symptoms by explaining 15.39% of its effect for urban-to-urban migrants and 18.97% for rural-to-urban migrants. Conclusions: Findings from this study reveal mental health inequalities among internal migrants and demonstrate the importance of social adaption on the association between social cohesion and depressive symptoms. Social strategies and public policies are needed to build a more cohesive community that serves both local residents and internal migrants, especially rural-to-urban migrants.

Prevalence and determinants of food insecurity during the 2022 COVID-19 related lockdown in Shanghai

Liu, Y., Li, G., Qi, X., Wu, B., Latkin, C. A., Tang, W., & Hall, B. J. (2023). Global Public Health, 18(1). 10.1080/17441692.2023.2246066
Abstract
Abstract
The SARS-CoV-2 coronavirus pandemic has led to increased food insecurity levels. This cross-sectional study examines the prevalence and determinants of food insecurity during the two-month (1 April to 1 June 2022) city-wide lockdown in Shanghai. The data was collected via an online questionnaire from 3230 adult Shanghai residents during the lockdown. Food insecurity was measured using an adapted version of the Household Food Insecurity Access Scale. Nearly 70% of participants reported being exposed to food insecurity. Using multivariable logistic regressions, we examined the associations between key correlates (i.e. age, income, lockdown-related income loss, migration, employment status, social capital, preparedness, and received social support) and overall food insecurity while adjusting for ethnicity, gender, education, household size, and marital status. Results showed that compared to local Shanghai residents, migrants (i.e, permanent migrants with Hukou (OR = 2.16), permanent migrants without Hukou (OR = 2.06), temporary migrants (OR = 2.74)), and participants with less than or greather than 50% lockdown-related income loss (OR = 2.60, OR = 3.09), were associated with higher odds of overall food insecurity. Participants with greater preparedness (OR = 0.66), greater bonding social capital (OR = 0.93), and greater bridging social capital (OR = 0.94), had lower odds of overall food insecurity. Targeted interventions are needed to enhance food resilience and health equity among vulnerable populations.

The promise and peril of ChatGPT in geriatric nursing education: What We know and do not know

Qi, X., Zhu, Z., & Wu, B. (2023). Aging and Health Research, 3(2). 10.1016/j.ahr.2023.100136

Sex differences in the mediating role of chronic inflammation on the association between social isolation and cognitive functioning among older adults in the United States

Qi, X., Ng, T. K. S., & Wu, B. (2023). Psychoneuroendocrinology, 149. 10.1016/j.psyneuen.2023.106023
Abstract
Abstract
Background: Previous research has reported the association between social isolation and cognitive impairment. However, biological mechanisms underlying this association are understudied. It is also unclear whether there are sex differences in these biological mechanisms. Objectives: To examine whether chronic inflammation biomarkers are potential mediators of the association between social isolation and cognitive functioning among older men and women. Methods: Data were the National Health and Nutrition Examination Survey 1999–2002. A total of 2535 older adults aged 60 and older were included. Chronic inflammation was measured by C-reactive protein (CRP), plasma fibrinogen, and serum albumin. Cognitive functioning was assessed by the Digit Symbol Substitution Test (DSST). Social isolation was defined using a 4-point composite index of items pertaining to the strength of social network and support. Linear regression models and formal mediation analysis were applied. Results: Social isolation was associated with lower DSST scores [β (SE) = −2.445 (1.180), p < 0.01 for men; β (SE) = −5.478 (1.167), p < 0.001 for women]. For older men, social isolation was associated with higher levels of CRP (β [SE] = 0.226 (0.110), p < 0.05) and fibrinogen (β [SE] = 0.058 (0.026), p < 0.05). In mediation analyses, among older men, CRP mediated 6.1% and fibrinogen mediated 12.0% of the association of social isolation with DSST. Conclusion: Social isolation was associated with poorer cognitive functioning partially via heightened inflammatory responses in older men. Defining these associations’ mechanisms in sex-specific contexts could inform preventive and therapeutic strategies for cognitive impairment in older adults.