Publications
Publications
Objectives and outcomes: The fundamental difference
Wittmann-Price, R. A., & Fasolka, B. J. (2010). Nursing Education Perspectives, 31(4), 233-236.
Abstract
This discussion focuses on the difference between educational objectives and outcomes. Both terms are used in nursing education, many times for the same purpose, yet they are expressions of different educational paradigms. A historical view of the development of objectives and outcomes is provided as well as a description of each.The discussion concludes with a demonstration of formats for developing educational outcomes.
Our sphere of influence: Are we doing all we can?
Newland, J. (2010). Nurse Practitioner, 35(5). 10.1097/01.NPR.0000371285.71448.7f
Overlap of registered nurse and physician practice: Implications for U.S. health care reform
Djukic, M., & Kovner, C. T. (2010). Policy, Politics, and Nursing Practice, 11(1), 13-22. 10.1177/1527154410365564
Abstract
This review offers an analysis of practice overlap between physicians and registered nurses (RNs) who are not advanced practice nurses. Additionally, it spotlights opportunities for expanding traditional professional boundaries to establish novel care delivery models. The examples of RN role expansion offer a beginning for discussion regarding how the health professionals' knowledge and skills can be best used in designing an effective and efficient health care system. Although limited data exist on cost effectiveness and workload implications of the novel care delivery models, policy makers can use the findings of this review to begin to inform U.S. health care reform.
Pack your bags for summer travel safety
Newland, J. (2010). Nurse Practitioner, 35(7). 10.1097/01.NPR.0000383650.91790.79
Partner selection among Latino immigrant men who have sex with men
Bianchi, F. T., Shedlin, M. G., Brooks, K. D., Penha, M. M., Reisen, C. A., Zea, M. C., & Poppen, P. J. (2010). Archives of Sexual Behavior, 39(6), 1321-1330. 10.1007/s10508-009-9510-x
Abstract
This qualitative study explored partner selection in a sample ofimmigrant Latino men who have sex with men (MSM). In-depth interviews were conducted with men living in the greater New York metropolitanarea who had been born in Brazil (n = 10), Colombia (n = 14), or the Dominican Republic (n = 9). One focus group was conducted with MSM from each of the three countries (9 Brazilian, 11 Colombian, and 5 Dominican participants). A grounded theory approach revealed three main themes relating to partner selection. The first concerned stereotypes of how Latino and Anglo-American men tendtobehaveintheir sexualencounters and relationships. The participants perceived Latinos to be more affectionate and passionate, whereas they saw Anglo-American men as more independent and practical. These cultural discrepancies sometimes resulted in a preference for Latino partners. A second theme concerned stereotypes of the national groups, including expectations that Brazilians would be sexy and sensual and that Dominicans would have large penises. As found in other research on MSM of color, ethnic and national stereotypes were associated with experiences of sexual objectification. The third theme addressed the importance of masculine characteristics in sexual attraction and partner selection. Negative feelings towards effeminate men who did not conform to normative male physical or behavioral presentation reflect a stigma found inside and outside of the gay community. These findings suggest that gender and ethnic stereotypes play an important role in shaping partner choice and have implications for sexual risk and relationship formation.
Perinatal safety: From concept to nursing practice
Lyndon, A., & Kennedy, H. P. (2010). Journal of Perinatal and Neonatal Nursing, 24(1), 22-31. 10.1097/JPN.0b013e3181cb9351
Abstract
Communication and teamwork problems are leading causes of documented preventable adverse outcomes in perinatal care. An essential component of perinatal safety is the organizational culture in which clinicians work. Clinicians' individual and collective authority to question the plan of care and take action to change the direction of a clinical situation in the patient's best interest can be viewed as their "agency for safety." However, collective agency for safety and commitment to support nurses in their role of advocacy is missing in many perinatal care settings. This article draws from Organizational Accident Theory, High Reliability Theory, and Symbolic Interactionism to describe the nurse's role in maintaining safety during labor and birth in acute care settings and suggests actions for supporting the perinatal nurse at individual, group, and systems levels to achieve maximum safety in perinatal care.
Physical work environment: Testing an expanded model of job satisfaction in a sample of registered nurses
Djukic, M., Kovner, C., Budin, W. C., & Norman, R. (2010). Nursing Research, 59(6), 441-451. 10.1097/NNR.0b013e3181fb2f25
Abstract
BACKGROUND: The impact of personal, organizational, and economic factors on nurses' job satisfaction have been studied extensively, but few studies exist in which the effects of physical work environment-including perceptions of architectural, interior design, and ambient features on job satisfaction-are examined. OBJECTIVES: The purpose of this study was to examine the effect of perceived physical work environment on job satisfaction, adjusting for multiple personal, organizational, and economic determinants of job satisfaction. METHODS: A cross-sectional, predictive design and a Web-based survey instrument were used to collect data from staff registered nurses in a large metropolitan hospital. The survey included 34 questions about multiple job satisfaction determinants, including 18 Likert-type measures with established good validity (comparative fit index = .97, Tucker-Lewis index = .98, root mean square error of approximation = .06) and reliability (r ≥ .70). RESULTS: A response rate of 48.5% resulted in a sample of 362, with 80% power to detect a medium effect of perceived physical environment on job satisfaction. On average, nurses had negative perceptions of physical work environment (M = 2.9, SD = 2.2). Although physical environment was related positively to job satisfaction (r =.256, p = .01) in bivariate analysis, in ordered probit regression, no effect of physical work environment on job satisfaction was found. DISCUSSION: In future studies, this relationship should be examined in larger and more representative samples of nurses. Qualitative methods should be used to explore how negatively perceived physical work environment impacts nurses. Rebuilding of U.S. hospitals, with a planned investment of $200 billion without considering how physical environment contributes to nurse work outcomes, threatens to exacerbate organizational nurse turnover.
Predictors of the trajectories of self-reported attentional fatigue in women with breast cancer undergoing radiation therapy
Merriman, J. D., Jansen, C., Koetters, T., West, C., Dodd, M., Lee, K., Paul, S. M., Aouizerat, B. E., Cooper, B. A., Swift, P. S., Wara, W., & Miaskowski, C. (2010). Oncology Nursing Forum, 37(4), 423-432. 10.1188/10.ONF.423-432
Abstract
Purpose/Objectives: To examine how attentional fatigue changed from the time of simulation to four months after the completion of radiation therapy and to investigate whether specific variables predicted initial levels and trajectories of attentional fatigue. Design: Descriptive, longitudinal study. Setting: Two radiation therapy departments. Sample: 73 women with breast cancer who received primary or adjuvant radiation therapy. Methods: Participants completed questionnaires prior to, during, and after radiation therapy. Descriptive statistics and hierarchical linear modeling were used for data analysis. Main Research Variables: Attentional fatigue; demographic, clinical, and symptom characteristics. Findings: Large amounts of interindividual variability were found in the trajectories of attentional fatigue. At baseline, higher levels of attentional fatigue were associated with younger age, not working, a higher number of comorbidities, and higher levels of trait anxiety. The trajectory of attentional fatigue improved over time for women with higher body mass index at baseline. Conclusions: This study is the first to identify predictors of interindividual variability in attentional fatigue in women with breast cancer undergoing radiation therapy. The predictors should be considered in the design of future correlational and interventional studies. Implications for Nursing: Nurses could use knowledge of the predictors to identify patients at risk for higher levels of attentional fatigue. In addition, nurses could use the information to educate patients about how attentional fatigue may change during and following radiation therapy for breast cancer.
Preliminary evidence of an association between a functional interleukin-6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers
Miaskowski, C., Dodd, M., Lee, K., West, C., Paul, S. M., Cooper, B. A., Wara, W., Swift, P. S., Dunn, L. B., & Aouizerat, B. E. (2010). Journal of Pain and Symptom Management, 40(4), 531-544. 10.1016/j.jpainsymman.2009.12.006
Abstract
Context: Fatigue and sleep disturbance are common problems in oncology patients and their family caregivers (FCs). However, little is known about factors that contribute to interindividual variability in these symptoms or to their underlying biologic mechanisms. Objectives: An evaluation was done on whether genetic variation in a prominent proinflammatory cytokine, interleukin-6 (IL-6 c.-6101A>T [rs4719714]), was associated with mean ratings of evening fatigue, morning fatigue, and sleep disturbance, as well as with the trajectories of these symptoms. Methods: Over six months, participants completed standardized measures of fatigue and sleep disturbance. Linear regression was used to assess the effect of the IL-6 genotype and other covariates on mean fatigue and sleep disturbance scores. Hierarchical linear modeling was used to determine the effect of the IL-6 genotype on symptom trajectories. Results: Common allele homozygotes reported higher levels of evening fatigue (P = 0.003), morning fatigue (P = 0.09), and sleep disturbance (P = 0.003) than minor allele carriers. Predictors of baseline level and trajectories of evening fatigue included age, gender, and genotype (intercepts) and baseline level of evening fatigue (slope). Predictors of baseline level and trajectories of morning fatigue included age and genotype (intercept) and age and baseline level of morning fatigue (slope). Predictors of baseline level and trajectories of sleep disturbance included age and genotype (intercept) and baseline level of sleep disturbance (slope). Conclusions: Findings provide preliminary evidence of a genetic association between a functional promoter polymorphism in the IL-6 gene and severity of evening fatigue, morning fatigue, and sleep disturbance in oncology patients and their FCs.
Prevalence and incidence of HCV infection among Vietnam heroin users with recent onset of injection
Clatts, M. C., Colón-López, V., Giang, L. M., & Goldsamt, L. A. (2010). Journal of Urban Health, 87(2), 278-291. 10.1007/s11524-009-9417-9
Abstract
HCV infection continues to spread at an alarming rate among IDU populations. The available evidence suggests that HCV is acquired relatively quickly following onset of injection. However, there are few prospective studies of HCV acquisition, particularly among IDU populations in resource-poor settings. A sample of young male heroin injectors with recent onset of injection (<4 years) was recruited in Hanoi, Vietnam for a prospective assessment of the early course of injection (n=179). Both behavioral and biological assessments (including detailed retrospective assessment of injection initiation) were conducted at baseline and repeated at 6-month intervals for a period of 16 months. Variables associated with HCV infection (p value<0.05) in bivariate analyses were considered for inclusion in logistic regression models to identify risk factors independently associated with HCV infection. HCV incidence was calculated by using the incidence density approach and was expressed in terms of person-years of observation. The baseline of prevalence of HCV was 46%. HCV significantly increased in relation to time since first injection, from 30% in subjects with ≤10 months of injection risk to 70% in subjects with ≥30 months injection risk (p value=0.0005). In multivariate logistic regression analysis, increasing age, incarceration in a drug detention facility (OR=2.54; 95%CI 1.05, 6.15), and time since first injection remained significantly associated with HCV infection. Use of injection as primary mode of administration (OR=2.56; 95%CI 0.98, 6.69) achieved marginal significance. After 16 months of follow-up, the incidence rate of HCV was 23.35 per 100 person-years and the mean time between first injection and first positive HCV test was 1.2 years. HCV is acquired much more rapidly among new injector populations than previously recognized, demonstrating the need for early behavioral intervention among new heroin-user populations. Particularly critical are interventions that target new heroin user populations, including interventions that improve understanding of viral transmission dynamics, that promote alternative strategies for drug sharing, and that delay initiation of injection.
Prevalence and predictors of adverse events in older surgical patients: Impact of the present on admission indicator
Kim, H., Capezuti, E., Kovner, C., Zhao, Z., & Boockvar, K. (2010). Gerontologist, 50(6), 810-820. 10.1093/geront/gnq045
Abstract
Purpose of the Study: To examine the effects of the present on admission (POA) indicator on the prevalence of and factors associated with postsurgical adverse events in older patients. Design and Methods: This is a secondary data analysis of 82,898 surgical patients aged 65 years or older in 252 acute care hospitals in California in 2004. Four adverse events were counted using the Agency for Healthcare Research and Quality's Patient Safety Indicator (PSI) definitions with and without using the POA indicator. We also examined the effects of the POA indicator on the relationships between patient- and hospital-level factors and adverse events, using generalized linear mixed models. Results: The use of the POA indicator resulted in a marked reduction in the estimated rates of all 4 adverse event rates. Adjustment for POA conditions also influenced factors associated with adverse events. Compared with those with newly occurring adverse events only, admissions with only POA conditions were more likely to be admitted through the emergency department, be unplanned, and belong to patients with one or more preceding admissions or those with multiple admissions within the same year. Implications: Adverse event rates estimated from discharge abstracts using PSI methodology could be overstated when the POA indicator was not used. The POA indicator could influence predictors of adverse events. Studies on geriatric safety and outcomes using large administrative data sets should consider using the POA indicator. Further studies are needed on how to determine POA conditions.
Prevalence of metabolic syndrome in South Asians residing in the United States
Flowers, E., Molina, C., Mathur, A., Prasad, M., Abrams, L., Sathe, A., Malhotra, D., Basra, R., Malgesini, N., Ratnam, G., Aouizerat, B. E., & Turakhia, M. P. (2010). Metabolic Syndrome and Related Disorders, 8(5), 417-423. 10.1089/met.2009.0097
Abstract
Aims/hypothesis: The aim of this study was to define the prevalence of the metabolic syndrome and its component risk factors among individuals of South Asian origin living in the United States. Methods: We analyzed baseline data from 1,445 participants enrolled in a cohort study investigating risk factors for cardiovascular disease in South Asians. We defined the metabolic syndrome using the International Diabetes Federation criteria for waist circumference (>90cm for men; >80cm, women), triglycerides (>150mg/dL), high-density lipoprotein cholesterol (HDL-C) (<40mg/dL (men), <45mg/dL (women)), blood pressure (>135/80mmHg), and fasting glucose (>100mg/dL). Results: The mean age was 43±10 years, and 30% of participants were women. The prevalence of metabolic syndrome was 27% (31% men vs. 17% women, P<0.05). Fifty-nine percent of the cohort had high waist circumference (58% men vs. 62% women, P = not significant [N.S.]), 47% had low HDL-C [46% men vs. 48% women (NS)], 19% had elevated triglycerides (23% men vs. 8% women, P<0.05), 14% had hypertension (16% men vs. 9% women, P< 0.05), and 13% had elevated fasting glucose (18% men vs. 11% women, P<0.05). The most common metabolic syndrome phenotype is low HDL-C with elevated triglycerides. Conclusions: Although the prevalence of the metabolic syndrome is lower than previous reports of South Asians, the prevalence is still unacceptably high despite the presence of protective demographic factors.
Preventive care is the wave of the future
Newland, J. (2010). Nurse Practitioner, 35(9). 10.1097/01.NPR.0000387145.95164.b8
Protective role of vitamin D against age-related macular degeneration: A hypothesis
Parekh, N. (2010). Topics in Clinical Nutrition, 25(4), 290-301. 10.1097/TIN.0b013e3181fabac1
Abstract
Age-related macular degeneration (AMD) is the leading cause of blindness among Americans. Local inflammation is implied in the pathophysiology of AMD that may cause photoreceptor destruction and blindness. Vitamin D may prevent AMD progression via its anti-inflammatory and antiangiogenic properties. Scientific evidence is discussed for the associations of vitamin D (serum, diet, and sunlight) and AMD. Evidence suggests inverse associations between serum vitamin D and its sources (specifically fish), and AMD. Associations with sunlight, hypothesized to increase risk for AMD, have been inconsistent possibly due to protection from vitamin D. Vitamin D may be a new protective factor against AMD.
Public health policy for management of hepatitis b virus infection: Historical review of recommendations for immunization
Lee, H., & Park, W. (2010). Public Health Nursing, 27(2), 148-157. 10.1111/j.1525-1446.2010.00842.x
Abstract
Chronic hepatitis B virus (HBV) infection is the leading cause of cirrhosis, liver failure, and liver cancer, and an estimated 620,000 persons die annually from HBV-related liver disease (Goldstein et al., 2005; World Health Organization, 2000). Immunization with the HBV vaccine is the most effective means of preventing HBV infection and its consequent acute and chronic liver diseases such as cirrhosis and hepatocellular carcinoma. The HBV vaccine has been used against HBV in the United States since 1982 (Centers for Disease Control and Prevention, 1982); during the last 25 years, HBV vaccine policy continued to evolve in response to public health issues and epidemiologic data. Although the number of newly acquired HBV infections has substantially declined as a result of implementation of a national immunization program, the prevalence of chronic HBV infection remains high. The purpose of this article is to review the epidemiology of HBV, provide a historical review of health policies for HBV immunization, and summarize the recent evidence-based public health guidelines for management of HBV infection in the United States.
Recruitment of rural and cognitively impaired older adults for dental research
Wu, B., Goedereis, E. A., Crout, R. J., Plassman, B. L., DiNapoli, E. A., McNeil, D. W., Wiener, M., Boone, M. L., Wiener, R. C., Kao, E., & Bai, L. (2010). Special Care in Dentistry, 30(5), 193-199. 10.1111/j.1754-4505.2010.00150.x
Abstract
The recruitment of community-dwelling older adults, particularly those with cognitive impairment and those residing in rural areas, has been consistently challenging for researchers, especially in the dental field. This study reports on recruitment experiences from an ongoing study investigating the association between oral health and cognitive status in later life. Multiple recruitment strategies, including educational presentations and traveling to participants' homes, were used to enroll rural elderly participants with various levels of cognitive function. In general, multipronged, proactive recruitment strategies were more effective than traditional, passive methods in reaching participants with varying degrees of cognitive impairment. The outcome of this study suggests that successful recruitment of such populations involves gaining the support of staff at relevant community organizations, informing community members (including older adults and their family members) of the project and the importance of oral health, and making data collection sites accessible for older adults.
Relationship between mood disturbance and sleep quality in oncology outpatients at the initiation of radiation therapy
Van Onselen, C., Dunn, L. B., Lee, K., Dodd, M., Koetters, T., West, C., Paul, S. M., Aouizerat, B. E., Wara, W., Swift, P., & Miaskowski, C. (2010). European Journal of Oncology Nursing, 14(5), 373-379. 10.1016/j.ejon.2009.12.002
Abstract
Purpose of the research: The purpose of this study was to describe the occurrence of significant mood disturbance and evaluate for differences in sleep quality among four mood groups (i.e., neither anxiety nor depression, only anxiety, only depression, anxiety and depression) prior to the initiation of radiation therapy (RT). Methods and sample: Patients (n=179) with breast, prostate, lung, and brain cancer were evaluated prior to the initiation of RT using the Pittsburgh Sleep Quality Index (PSQI), the Center for Epidemiological Studies Depression Scale, and the Spielberger State Anxiety Inventory. Differences in sleep disturbance among the four mood groups were evaluated using analyses of variance. Key results: While 38% of the patients reported some type of mood disturbance, 57% of the patients reported sleep disturbance. Patients with clinically significant levels of anxiety and depression reported the highest levels of sleep disturbance. Conclusions: Overall, oncology patients with mood disturbances reported more sleep disturbance than those without mood disturbance. Findings suggest that oncology patients need to be assessed for mood and sleep disturbances.
Religion and spirituality among black Americans
Newlin, K., & Melkus, G. (2010). Practical Diabetology, 29(4), 26-30.
Religious congregations and the growing needs of older adults with HIV
Brennan, M., Strauss, S. M., & Karpiak, S. E. (2010). Journal of Religion, Spirituality and Aging, 22(4), 307-328. 10.1080/15528030.2010.499746
Abstract
By 2015, half of those with HIV will be over age 50. This group has a high level of needs, lacks social supports, and will need to access community services such as those provided by religious congregations. We examined whether disclosure to a congregation would pose a barrier to accessing congregational services among adults 50 and older with HIV (n = 819). Fifty-three percent had disclosed, but those who did not disclose generally remained engaged with their congregations. Findings suggest that congregations can be a feasible source of support for older adults with HIV.
Research note: Perspectives on the hierarchy of HIV and hepatitis C disease: Consequences for drug treatment program patients
Munoz-Plaza, C., Strauss, S. M., Tiburcio, N., Astone-Twerell, J. M., Des Jarlais, D. C., Gwadz, M., Hagan, H., Osborne, A., & Rosenblum, A. (2010). Journal of Drug Issues, 40(2), 517-536. 10.1177/002204261004000211
Abstract
Injection drug users (IDUs) face an increased risk of acquiring blood borne viral infections, including HIV and the hepatitis C virus (HCV). However, the discrepancy in funding for services to address these two diseases has implications. Although drug treatment programs have played an important role in fighting HIV/AIDS, the HCV-related services offered at these programs remain limited. Research from other countries suggests that drug users view HCV as less important than HIV, yet little is known about the extent to which our society's focus on HIV has been adopted within the drug treatment program culture. This qualitative study examines the perceptions of both staff (n = 165) and clients (n = 215) at these programs with regard to HIV and HCV and presents data on how staffs' attitudes toward HCV changed after participating in an HCV training. Clients described a services landscape at drug treatment programs that favors HIV services over those targeting HCV.
Researchers and productivity metrics: The tail that wags the dog?
Clarke, S. P. (2010). Canadian Journal of Nursing Research, 42(4), 5-8.
Risk Factors and Symptoms Associated With Pain in HIV-Infected Adults
Aouizerat, B. E., Miaskowski, C. A., Gay, C., Portillo, C. J., Coggins, T., Davis, H., Pullinger, C. R., & Lee, K. A. (2010). Journal of the Association of Nurses in AIDS Care, 21(2), 125-133. 10.1016/j.jana.2009.10.003
Abstract
Studies suggest that people living with HIV (PLWH) experience many unrelieved symptoms. The purpose of this study was to estimate the occurrence of pain in adult PLWH and to determine whether participants with pain differed from those without pain on selected demographic factors, clinical characteristics, symptoms of fatigue, sleep disturbance, anxiety, or depression. The authors conducted a descriptive, comparative, and correlational study of 317 PLWH seen at academic and community clinics in San Francisco. Participants completed a demographic questionnaire, the Memorial Symptom Assessment Scale, the Fatigue Severity Scale, the General Sleep Disturbance Scale, the Profile of Moods State Tension-Anxiety subscale, and the Center for Epidemiological Studies-Depression Scale. Clinical characteristics (i.e., disease and treatment information) were obtained by self-report. A single item on pain from the Memorial Symptom Assessment Scale was used to classify participants into those with and without pain. Pain was highly prevalent (55%) and was associated with immune status (CD4+ T-cell count), race, and sleep disturbance, but not with age, gender, or symptoms of fatigue, depression, or anxiety.
Scheduled and unscheduled hospital readmissions among patients with diabetes
Kim, H., Ross, J. S., Melkus, G. D., Zhao, Z., & Boockvar, K. (2010). American Journal of Managed Care, 16(10), 760-767.
Abstract
Objectives: To describe rates of scheduled and unscheduled readmissions among midlife and older patients with diabetes and to examine associated socioeconomic and clinical factors. Study Design: Population-based data set study. Methods: Using the 2006 California State Inpatient Dataset, we identified 124,967 patients 50 years or older with diabetes who were discharged from acute care hospitals between April and September 2006 and examined readmissions in the 3 months following their index hospitalizations. Results: About 26.3% of patients were readmitted within the 3-month period following their index hospitalizations, 87.2% of which were unscheduled readmissions. Patients with unscheduled readmissions were more likely to have a higher comorbidity burden, be members of racial/ethnic minority groups with public insurance, and live in lower-income neighborhoods. Having a history of hospitalization in the 3 months preceding the index hospitalization was also a strong predictor of unscheduled readmissions. Almost one-fifth of unscheduled readmissions (constituting approximately 27,500 inpatient days and costing almost $72.7 million) were potentially preventable based on definitions of Prevention Quality Indicators by the Agency for Healthcare Research and Quality. Scheduled readmissions were less likely to occur among patients 80 years or older, the uninsured, and those with an unscheduled index hospitalization. Conclusions: The predictors of scheduled and unscheduled readmissions are different. Transition care to prevent unscheduled readmissions in acutely ill patients with diabetes may help reduce rates, improving care. Further studies are needed on potential disparities in scheduled readmissions.
School nurses save lives: Can we provide the data?
Malone, K. M., & Bergren, D. B. (2010). Journal of School Nursing, 26(5), 344-351. 10.1177/1059840510376384
Abstract
Vigilance has been central to nursing practice since Florence Nightingale. Often, the nurse's work of surveillance goes unnoticed and the public never recognizes the value of the nurse's work. The 1999 Institute of Medicine report on hospital deaths due to preventable errors has lifted the veil shrouding professional vigilance. But how to measure vigilance remained elusive, until the concept, failure to rescue (FTR), was proposed. FTR has taken a prominent role in health care since its adoption as a patient safety indicator by the Agency for Healthcare Research and Quality (AHRQ) and as a measure for nursing performance in acute care by the National Quality Forum (NQF). However, its applicability to school nursing has been unexplored. This article provides an initial review of the literature and an analysis of anecdotal stories and media accounts that illustrate professional vigilance in school nursing practice.
Second trimester serum predictors of preterm birth in a population-based sample of low-risk pregnancies
Jelliffe-Pawlowski, L. L., Baer, R. J., & Currier, R. J. (2010). Prenatal Diagnosis, 30(8), 727-733. 10.1002/pd.2489
Abstract
Objective: To examine the relationship between typically collected second trimester maternal serum biomarkers and preterm birth among pregnancies without intrauterine-growth-retardation or other specific risk factors. Methods: Included were 102 861 singleton pregnancies without specific risks that resulted in the live birth of an infant of normal birth weight for gestational age without aneuploidy or a neural tube defect. Logistic binomial regression analyses were used to estimate the relative risk (RR) of giving birth preterm among pregnancies with an abnormal level of alpha-fetoprotein (AFP), human chorionic gonatotropin (hCG), and/or unconjugated estriol (uE3) compared to pregnancies with normal biomarker levels. Results: When compared to pregnancies with normal levels of AFP, hCG, and uE3, pregnancies with elevated levels of any biomarker [multiple of the median (MoM) ≥2.0] were at an increased risk for preterm birth regardless of preterm grouping (RRs 1.3-5.4). Risks for preterm birth tended to increase substantially when at least two biomarkers were elevated (RRs 2.2-18.7). Conclusion: The results suggest that second trimester maternal serum biomarkers may help identify pregnancies at increased risk for preterm birth when no other identified risks are present. Data indicates that biomarkers may be particularly predictive of early preterm birth.