Laura Jelliffe-Pawlowski

Faculty

Jelliffe-Pawlowski Headsot

Laura Jelliffe-Pawlowski

PhD MS

Florence S. and William H. Downs Professor in Nursing Research
Senior Associate Dean of Research

1 212 998 9020

433 First Ave
New York, NY 10010
United States

Laura Jelliffe-Pawlowski's additional information

Laura Jelliffe-Pawlowski, PhD, MS, is a Professor at NYU Rory Meyers College of Nursing. Prof. Jelliffe-Pawlowski’s research interests focus on understanding and addressing the drivers and consequences of adverse pregnancy outcomes with a special emphasis on preterm birth and associated racial/ethnic and socioeconomic inequities. Her work is highly transdisciplinary and looks at the interplay of biomolecular, social, and policy factors in observed patterns and outcomes. Her teaching and mentorship activities reflect this transdisciplinary approach with an emphasis on motivating the translation of research findings into action.

Jelliffe-Pawlowski leads a number of statewide, national, and international research efforts funded by the National Institutes of Health, the Bill and Melinda Gates Foundation, the March of Dimes, the State of California, and other entities. These includes, notably, the “Healthy Outcomes of Pregnancy for Everyone (HOPE)” consortium and study which focuses on understanding the experience of pregnant people and their infants pre- and post-COVID 19 pandemic. HOPE examines how biomolecular, social, and community factors affect the well-being and outcomes of mothers and infants and includes enrollment during pregnancy with outcome follow-up to 18-months after birth. Other ongoing projects include, for example, the NIH funded “Prediction Of Maturity, Morbidity, and Mortality in PreTerm Infants (PROMPT)”, study which focuses on examining the metabolic profiles of newborns with early preterm birth and associated outcomes, the “Transforming Health and Reducing PerInatal Anxiety through Virtual Engagement (THRIVE)”, randomized control trial (RCT), funded by the State of California which examines whether digital cognitive behavior therapy delivered by mobile app can assist in reducing anxiety symptoms in pregnant people and also examines participant acceptability of the application. Ongoing efforts also include leading the “California Prediction of Poor Outcomes of Pregnancy (CPPOP)” cohort study which focuses on investigating multi-omic drivers of preterm birth. The study interrogates biomolecular signals associated with preterm birth and includes full genome sequencing and mid-pregnancy biomolecular signaling related to metabolic, immune, stress, and placental function in hundreds of pregnancies with and without preterm birth.

Prior to her joining NYU Rory Meyers College of Nursing, Jelliffe-Pawlowski was a Professor of Epidemiology & Biostatistics, Chief of the Division of Lifecourse Epidemiology, a Professor in the Institute of Global Health Sciences, and Director of Discovery and Precision Health for the UCSF California Preterm Birth Initiative in the University of California San Francisco (UCSF) School of Medicine. She has a lifetime appointment as an Emeritus Professor of Epidemiology & Biostatistics in the UCSF School of Medicine and continues to work closely with the new Center for Birth Equity at UCSF. Prior to her appointment at UCSF, she was a leader at the Genetic Disease Screening Program within the California Department of Public Health.

Jelliffe-Pawlowski efforts have been highlighted in numerous academic and lay articles including in the New York Times, in WIRED Magazine, in the Atlantic, on CNN, and on MSNBC. In 2023, she was recognized by Forbes Magazine as one of the top 50 over 50 Innovators in the United States. She is also a Phase I and Phase II Bill and Melinda Gates Foundation Grand Challenges awardee for her work in the United States and Uganda which focused on the development and validation of newborn metabolic profile as a novel measure of gestational age in infants.

PhD in Human Development, University of California Davis
MS in Child Development, University of California Davis
BA in Psychology, University of California Los Angeles
Preterm Birth

Faculty Honors Awards

Forbes 50 over 50 awardee in Innovation (2023)
Delegate, African Academy of Sciences (2016)
Awardee, Bill and Melinda Bates Foundation, Gates Grand Challenges Phase I and II
Governor Brown Appointee for the California Department of Public Health, Interagency Coordinating Council on Early Intervention

Publications

Residential particulate matter, proximity to major roads, traffic density and traffic volume as risk factors for preterm birth in California

Costello, J. M., Steurer, M. A., Baer, R. J., Witte, J. S., & Jelliffe-Pawlowski, L. (2022). In Paediatric and Perinatal Epidemiology (Vols. 36, Issue 1, pp. 70-79). 10.1111/ppe.12820
Abstract
Abstract
Background: While pollution from vehicle sources is an established risk factor for preterm birth, it is unclear whether distance of residence to the nearest major road or related measures like major road density represent useful measures for characterising risk. Objective: To determine whether major road proximity measures (including distance to major road, major road density and traffic volume) are more useful risk factors for preterm birth than other established vehicle-related measures (including particulate matter

Risk of early birth by body mass index in a propensity score-matched sample : A retrospective cohort study

Baer, R. J., Chambers, B. D., Coleman-Phox, K., Flowers, E., Fuchs, J. D., Oltman, S. P., Scott, K. A., Ryckman, K. K., Rand, L., & Jelliffe-Pawlowski, L. (2022). In BJOG: An International Journal of Obstetrics and Gynaecology (Vols. 129, Issues 10, pp. 1704-1711). 10.1111/1471-0528.17120
Abstract
Abstract
Objective: Evaluate the risk of preterm (

Risk Factors for Dual Burden of Severe Maternal Morbidity and Preterm Birth by Insurance Type in California

Jelliffe-Pawlowski, L., El Ayadi, A. M., Baer, R. J., Gay, C., Lee, H. C., Obedin-Maliver, J., Jelliffe-Pawlowski, L., & Lyndon, A. (2022). In Maternal and child health journal (Vols. 26, Issues 3, pp. 601-613).
Abstract
Abstract
Among childbearing women, insurance coverage determines degree of access to preventive and emergency care for maternal and infant health. Maternal-infant dyads with dual burden of severe maternal morbidity and preterm birth experience high physical and psychological morbidity, and the risk of dual burden varies by insurance type. We examined whether sociodemographic and perinatal risk factors of dual burden differed by insurance type.

Risk factors for neonatal encephalopathy in late preterm and term singleton births in a large California birth cohort

Bandoli, G., Suttner, D., Kiernan, E., Baer, R. J., Jelliffe-Pawlowski, L., & Chambers, C. D. (2022). In Journal of Perinatology (Vols. 42, Issues 3, pp. 341-347). 10.1038/s41372-021-01242-z
Abstract
Abstract
Objective: The objective was to investigate maternal and pregnancy characteristics associated with neonatal encephalopathy (NE). Study design: We queried an administrative birth cohort from California between 2011 and 2017 to determine the association between each factor and NE with and without hypothermia treatment. Results: From 3 million infants born at 35 or more weeks of gestation, 6,857 cases of NE were identified (2.3 per 1000 births), 888 (13%) received therapeutic hypothermia. Risk factors for NE were stronger among cases receiving hypothermia therapy. Substance-related diagnosis, preexisting diabetes, preeclampsia, and any maternal infection were associated with a two-fold increase in risk. Maternal overweight/obesity, nulliparity, advanced maternal age, depression, gestational diabetes or hypertension, and short or long gestations also predicted NE. Young maternal age, Asian race and Hispanic ethnicity, and cannabis-related diagnosis lowered risk of NE. Conclusions: By disseminating these results, we encourage further interrogation of these perinatal factors.

The risk of preterm birth among women with a history of leukemia or lymphoma

Anand, S. T., Chrischilles, E. A., Baer, R. J., Charlton, M. E., Breheny, P. J., Terry, W. W., McLemore, M. R., Karasek, D. A., Jelliffe-Pawlowski, L., & Ryckman, K. K. (2022). In Journal of Maternal-Fetal and Neonatal Medicine (Vols. 35, Issues 25, pp. 6115-6123). 10.1080/14767058.2021.1907332
Abstract
Abstract
Objective: Leukemia and lymphoma are top cancers affecting children, adolescents and young adults with high five-year survival rates. Late effects of these cancers are a concern in reproductive-age patients, including pregnancy outcomes such as preterm birth. Our study aimed to evaluate whether diagnosis of leukemia or lymphoma prior to pregnancy was associated with preterm birth (

Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus

Jelliffe-Pawlowski, L., Lewis, K. A., Chang, L., Cheung, J., Aouizerat, B. E., Jelliffe-Pawlowski, L. L., McLemore, M. R., Piening, B., Rand, L., Ryckman, K. K., & Flowers, E. (2022). In Frontiers in endocrinology (Vols. 13, p. 971354).
Abstract
Abstract
Gestational diabetes (GDM) is associated with increased risk for preterm birth and related complications for both the pregnant person and newborn. Changes in gene expression have the potential to characterize complex interactions between genetic and behavioral/environmental risk factors for GDM. Our goal was to summarize the state of the science about changes in gene expression and GDM.

Targeted newborn metabolomics : prediction of gestational age from cord blood

Jasper, E. A., Oltman, S. P., Rogers, E. E., Dagle, J. M., Murray, J. C., Kamya, M., Kakuru, A., Kajubi, R., Ochieng, T., Adrama, H., Okitwi, M., Olwoch, P., Jagannathan, P., Clark, T. D., Dorsey, G., Ruel, T., Jelliffe-Pawlowski, L., & Ryckman, K. K. (2022). In Journal of Perinatology (Vols. 42, Issues 2, pp. 181-186). 10.1038/s41372-021-01253-w
Abstract
Abstract
Objective: Our study sought to determine whether metabolites from a retrospective collection of banked cord blood specimens could accurately estimate gestational age and to validate these findings in cord blood samples from Busia, Uganda. Study Design: Forty-seven metabolites were measured by tandem mass spectrometry or enzymatic assays from 942 banked cord blood samples. Multiple linear regression was performed, and the best model was used to predict gestational age, in weeks, for 150 newborns from Busia, Uganda. Results: The model including metabolites and birthweight, predicted the gestational ages within 2 weeks for 76.7% of the Ugandan cohort. Importantly, this model estimated the prevalence of preterm birth

The association between preterm birth and postpartum mental healthcare utilization among California birthing people

Jelliffe-Pawlowski, L., Calthorpe, L. M., Baer, R. J., Chambers, B. D., Steurer, M. A., Shannon, M. T., Oltman, S. P., Karvonen, K. L., Rogers, E. E., Rand, L. I., Jelliffe-Pawlowski, L. L., & Pantell, M. S. (2021). In American journal of obstetrics & gynecology MFM (Vols. 3, Issues 4, p. 100380).
Abstract
Abstract
While mental health conditions such as postpartum depression are common, little is known about how mental healthcare utilization varies after term versus preterm delivery.

The association between preterm birth and postpartum mental healthcare utilization among California birthing people

Calthorpe, L. M., Baer, R. J., Chambers, B. D., Steurer, M. A., Shannon, M. T., Oltman, S. P., Karvonen, K. L., Rogers, E. E., Rand, L. I., Jelliffe-Pawlowski, L., & Pantell, M. S. (2021). In American Journal of Obstetrics and Gynecology MFM (Vols. 3, Issues 4). 10.1016/j.ajogmf.2021.100380
Abstract
Abstract
BACKGROUND: While mental health conditions such as postpartum depression are common, little is known about how mental healthcare utilization varies after term versus preterm delivery. OBJECTIVE: This study aimed to determine whether preterm birth is associated with postpartum inpatient and emergency mental healthcare utilization. STUDY DESIGN: The study sample was obtained from a database of live-born neonates delivered in California between the years of 2011 and 2017. The sample included all people giving birth to singleton infants between the gestational age of 20 and 44 weeks. Preterm birth was defined as

Association between Z-score for birth weight and postoperative outcomes in neonates and infants with congenital heart disease

Steurer, M. A., Peyvandi, S., Costello, J. M., Moon-Grady, A. J., Habib, R. H., Hill, K. D., Jacobs, M. L., Jelliffe-Pawlowski, L., Keller, R. L., Pasquali, S. K., Reddy, V. M., Tabbutt, S., & Rajagopal, S. (2021). In Journal of Thoracic and Cardiovascular Surgery (Vols. 162, Issues 6, pp. 1838-1847.e4). 10.1016/j.jtcvs.2021.01.065
Abstract
Abstract
Objective: We hypothesized that infants with fetal growth restrictions have increased mortality and morbidity after congenital heart disease surgery. Methods: The study included patients in The Society of Thoracic Surgeons Congenital Heart Surgery Database (2010-2016) who underwent cardiac surgery at a corrected gestational age of ≤44 weeks. Patients were classified as severely (birth weight Z-score −4 to −2), moderately (Z-score −2 to −1), and mildly growth restricted (Z-score −1.0 to −0.5) and compared with a reference population (Z-score 0-0.5). Multivariable logistic regression clustering on center was used to evaluate the association of birth weight Z-score with operative mortality and postoperative complications and its interaction with gestational age was assessed. Results: In 25,244 patients, operative mortality was 8.6% and major complications occurred in 19.4%. Compared with the reference group, the adjusted odds ratio (AOR) of mortality was increased in infants with severe (AOR, 2.4; 95% confidence interval [CI], 2.0-3.0), moderate (AOR, 1.7; 95% CI, 1.4-2.0), and mild growth restriction (AOR, 1.4; 95% CI, 1.2-1.6). The AOR for major postoperative complications was increased for severe (AOR, 1.4; 95% CI, 1.2-1.7) and moderate growth restriction (AOR, 1.2; 95% CI, 1.1-1.4). There was significant interaction between birth weight Z-score and gestational age (P = .007). Conclusions: Even birth weight Z-scores slightly below average are independent risk factors for mortality and morbidity in infants who undergo cardiac surgery. The strongest association between poor fetal growth and operative mortality exists in early-term infants. These novel findings might account for some of the previously unexplained variation in cardiac surgical outcomes.

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