Laura Jelliffe-Pawlowski

Faculty

Jelliffe-Pawlowski Headsot

Laura Jelliffe-Pawlowski

PhD MS

Florence S. and William H. Downs Professor in Nursing Research
Senior Associate Dean of Research

1 212 998 9020

433 First Ave
New York, NY 10010
United States

Laura Jelliffe-Pawlowski's additional information

Laura Jelliffe-Pawlowski, PhD, MS, is a Professor at NYU Rory Meyers College of Nursing. Prof. Jelliffe-Pawlowski’s research interests focus on understanding and addressing the drivers and consequences of adverse pregnancy outcomes with a special emphasis on preterm birth and associated racial/ethnic and socioeconomic inequities. Her work is highly transdisciplinary and looks at the interplay of biomolecular, social, and policy factors in observed patterns and outcomes. Her teaching and mentorship activities reflect this transdisciplinary approach with an emphasis on motivating the translation of research findings into action.

Jelliffe-Pawlowski leads a number of statewide, national, and international research efforts funded by the National Institutes of Health, the Bill and Melinda Gates Foundation, the March of Dimes, the State of California, and other entities. These includes, notably, the “Healthy Outcomes of Pregnancy for Everyone (HOPE)” consortium and study which focuses on understanding the experience of pregnant people and their infants pre- and post-COVID 19 pandemic. HOPE examines how biomolecular, social, and community factors affect the well-being and outcomes of mothers and infants and includes enrollment during pregnancy with outcome follow-up to 18-months after birth. Other ongoing projects include, for example, the NIH funded “Prediction Of Maturity, Morbidity, and Mortality in PreTerm Infants (PROMPT)”, study which focuses on examining the metabolic profiles of newborns with early preterm birth and associated outcomes, the “Transforming Health and Reducing PerInatal Anxiety through Virtual Engagement (THRIVE)”, randomized control trial (RCT), funded by the State of California which examines whether digital cognitive behavior therapy delivered by mobile app can assist in reducing anxiety symptoms in pregnant people and also examines participant acceptability of the application. Ongoing efforts also include leading the “California Prediction of Poor Outcomes of Pregnancy (CPPOP)” cohort study which focuses on investigating multi-omic drivers of preterm birth. The study interrogates biomolecular signals associated with preterm birth and includes full genome sequencing and mid-pregnancy biomolecular signaling related to metabolic, immune, stress, and placental function in hundreds of pregnancies with and without preterm birth.

Prior to her joining NYU Rory Meyers College of Nursing, Jelliffe-Pawlowski was a Professor of Epidemiology & Biostatistics, Chief of the Division of Lifecourse Epidemiology, a Professor in the Institute of Global Health Sciences, and Director of Discovery and Precision Health for the UCSF California Preterm Birth Initiative in the University of California San Francisco (UCSF) School of Medicine. She has a lifetime appointment as an Emeritus Professor of Epidemiology & Biostatistics in the UCSF School of Medicine and continues to work closely with the new Center for Birth Equity at UCSF. Prior to her appointment at UCSF, she was a leader at the Genetic Disease Screening Program within the California Department of Public Health.

Jelliffe-Pawlowski efforts have been highlighted in numerous academic and lay articles including in the New York Times, in WIRED Magazine, in the Atlantic, on CNN, and on MSNBC. In 2023, she was recognized by Forbes Magazine as one of the top 50 over 50 Innovators in the United States. She is also a Phase I and Phase II Bill and Melinda Gates Foundation Grand Challenges awardee for her work in the United States and Uganda which focused on the development and validation of newborn metabolic profile as a novel measure of gestational age in infants.

PhD in Human Development, University of California Davis
MS in Child Development, University of California Davis
BA in Psychology, University of California Los Angeles
Preterm Birth

Faculty Honors Awards

Forbes 50 over 50 awardee in Innovation (2023)
Delegate, African Academy of Sciences (2016)
Awardee, Bill and Melinda Bates Foundation, Gates Grand Challenges Phase I and II
Governor Brown Appointee for the California Department of Public Health, Interagency Coordinating Council on Early Intervention

Publications

The association of COVID-19 infection in pregnancy with preterm birth : A retrospective cohort study in California

Karasek, D., Baer, R. J., McLemore, M. R., Bell, A. J., Blebu, B. E., Casey, J. A., Coleman-Phox, K., Costello, J. M., Felder, J. N., Flowers, E., Fuchs, J. D., Gomez, A. M., Karvonen, K., Kuppermann, M., Liang, L., McKenzie-Sampson, S., McCulloch, C. E., Oltman, S. P., Pantell, M. S., … Jelliffe-Pawlowski, L. (2021). In The Lancet Regional Health - Americas (Vols. 2). 10.1016/j.lana.2021.100027
Abstract
Abstract
Introduction: Our understanding of the association between coronavirus disease 19 (COVID-19) and preterm or early term birth among racially and ethnically diverse populations and people with chronic medical conditions is limited. Methods: We determined the association between COVID-19 and preterm (PTB) birth among live births documented by California Vital Statistics birth certificates between July 2020 and January 2021 (n=240,147). We used best obstetric estimate of gestational age to classify births as very preterm (VPTB,

The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California

Jelliffe-Pawlowski, L., Karasek, D., Baer, R. J., McLemore, M. R., Bell, A. J., Blebu, B. E., Casey, J. A., Coleman-Phox, K., Costello, J. M., Felder, J. N., Flowers, E., Fuchs, J. D., Gomez, A. M. M., Karvonen, K., Kuppermann, M., Liang, L., McKenzie-Sampson, S., McCulloch, C. E., Oltman, S. P., … Jelliffe-Pawlowski, L. L. (2021). In Lancet regional health. Americas (Vols. 2, p. 100027).
Abstract
Abstract
Our understanding of the association between coronavirus disease 19 (COVID-19) and preterm or early term birth among racially and ethnically diverse populations and people with chronic medical conditions is limited.

Association of Maternal Immune Activation during Pregnancy and Neurologic Outcomes in Offspring

Jain, S., Baer, R. J., McCulloch, C. E., Rogers, E., Rand, L., Jelliffe-Pawlowski, L., & Piao, X. (2021). In Journal of Pediatrics (Vols. 238, pp. 87-93.e3). 10.1016/j.jpeds.2021.04.069
Abstract
Abstract
Objective: To evaluate neurologic morbidity among offspring during their first year of life in association with prenatal maternal immune activation (MIA), using an inclusive definition. Study design: This retrospective cohort study included singletons born in California between 2011 and 2017. MIA was defined by International Classification of Diseases diagnosis of infection, autoimmune disorder, allergy, asthma, atherosclerosis, or malignancy during pregnancy. Neurologic morbidity in infants was defined by International Classification of Diseases diagnosis of intraventricular hemorrhage, periventricular leukomalacia, seizures, abnormal neurologic examination, or abnormal neurologic imaging. Outcomes of delayed developmental milestones during the first year of life were also explored. Risk of neurologic morbidity in offspring was approximated for women with and without MIA using log link binary regression. Results: Demographic characteristics among 3 004 166 mother-infant dyads with or without MIA were similar in both groups. Rate of preterm delivery in mothers with MIA (9.4%) was significantly higher than those without MIA (5.6%). Infants of mothers with MIA were more likely to experience neurologic morbidities across all gestational ages. Adjusted relative risk (95% CI) in the exposed infants was 2.0 (1.9-2.1) for abnormal neurologic examination; 1.6 (1.5-1.7) for seizures, and 1.6 (1.4-1.8) for periventricular leukomalacia. Conclusions: Our results demonstrate that MIA during pregnancy may be associated with considerably higher risk of neurologic morbidity in offspring.

Association of maternal prenatal selenium concentration and preterm birth : A multicountry meta-analysis

Monangi, N., Xu, H., Khanam, R., Khan, W., Deb, S., Pervin, J., Price, J. T., Kennedy, S. H., Al Mahmud, A., Fan, Y., Le, T. Q., Care, A., Landero, J. A., Combs, G. F., Belling, E., Chappell, J., Kong, F., Lacher, C., Ahmed, S., … Muglia, L. (2021). In BMJ Global Health (Vols. 6, Issues 9). 10.1136/bmjgh-2021-005856
Abstract
Abstract
Background Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples collected from diverse populations. Methods Gestational duration data and maternal plasma or serum samples of 9946 singleton live births were obtained from 17 geographically diverse study cohorts. Maternal Se concentrations were determined by inductively coupled plasma mass spectrometry analysis. The associations between maternal Se with PTB and gestational duration were analysed using logistic and linear regressions. The results were then combined using fixed-effect and random-effect meta-analysis. Findings In all study samples, the Se concentrations followed a normal distribution with a mean of 93.8 ng/mL (SD: 28.5 ng/mL) but varied substantially across different sites. The fixed-effect meta-analysis across the 17 cohorts showed that Se was significantly associated with PTB and gestational duration with effect size estimates of an OR=0.95 (95% CI: 0.9 to 1.00) for PTB and 0.66 days (95% CI: 0.38 to 0.94) longer gestation per 15 ng/mL increase in Se concentration. However, there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance. The largest effect sizes were observed in UK (Liverpool) cohort, and most significant associations were observed in samples from Malawi. Interpretation While our study observed statistically significant associations between maternal Se concentration and PTB at some sites, this did not generalise across the entire cohort. Whether population-specific factors explain the heterogeneity of our findings warrants further investigation. Further evidence is needed to understand the biologic pathways, clinical efficacy and safety, before changes to antenatal nutritional recommendations for Se supplementation are considered.

Brief report : Acute care visits vary by race and ethnicity among publicly insured preterm infants

Karvonen, K. L., Baer, R. J., Rogers, E. E., Steurer, M. A., Jelliffe-Pawlowski, L., & Pantell, M. S. (2021). In Pediatric Research (Vols. 90, Issues 4, pp. 712-716). 10.1038/s41390-021-01504-8
Abstract
Abstract
~

Cannabis-related diagnosis in pregnancy and adverse maternal and infant outcomes

Jelliffe-Pawlowski, L., Bandoli, G., Jelliffe-Pawlowski, L., Schumacher, B., Baer, R. J., Felder, J. N., Fuchs, J. D., Oltman, S. P., Steurer, M. A., & Marienfeld, C. (2021). In Drug and alcohol dependence (Vols. 225, p. 108757).
Abstract
Abstract
Cannabis use and cannabis use disorders are increasing in prevalence, including among pregnant women. The objective was to evaluate the association of a cannabis-related diagnosis (CRD) in pregnancy and adverse maternal and infant outcomes.

Cannabis-related diagnosis in pregnancy and adverse maternal and infant outcomes

Bandoli, G., Jelliffe-Pawlowski, L., Schumacher, B., Baer, R. J., Felder, J. N., Fuchs, J. D., Oltman, S. P., Steurer, M. A., & Marienfeld, C. (2021). In Drug and alcohol dependence (Vols. 225). 10.1016/j.drugalcdep.2021.108757
Abstract
Abstract
Background: Cannabis use and cannabis use disorders are increasing in prevalence, including among pregnant women. The objective was to evaluate the association of a cannabis-related diagnosis (CRD) in pregnancy and adverse maternal and infant outcomes. Methods: We queried an administrative birth cohort of singleton deliveries in California between 2011–2017 linked to maternal and infant hospital discharge records. We classified pregnancies with CRD from International Classification of Disease codes. We identified nicotine and other substance-related diagnoses (SRD) in the same manner. Outcomes of interest included maternal (hypertensive disorders) and infant (prematurity, small for gestational age, NICU admission, major structural malformations) adverse outcomes. Results: From 3,067,069 pregnancies resulting in live births, 29,112 (1.0 %) had a CRD. CRD was associated with an increased risk of all outcomes studied; the strongest risks observed were for very preterm birth (aRR 1.4, 95 % CI 1.3, 1.6) and small for gestational age (aRR 1.4, 95 % CI 1.3, 1.4). When analyzed with or without co-exposure diagnoses, CRD alone conferred increased risk for all outcomes compared to no use. The strongest effects were seen for CRD with other SRD (preterm birth aRR 2.3, 95 % CI 2.2, 2.5; very preterm birth aRR 2.6, 95 % CI 2.3, 3.0; gastrointestinal malformations aRR 2.0, 95 % CI 1.6, 2.6). The findings were generally robust to unmeasured confounding and misclassification analyses. Conclusions: CRD in pregnancy was associated with increased risk of adverse maternal and infant outcomes. Providing education and effective treatment for women with a CRD during prenatal care may improve maternal and infant health.

Correction : Racial and ethnic disparities in outcomes through 1 year of life in infants born prematurely: a population based study in California (Journal of Perinatology, (2021), 41, 2, (220-231), 10.1038/s41372-021-00919-9)

Karvonen, K. L., Baer, R. J., Rogers, E. E., Steurer, M. A., Ryckman, K. K., Feuer, S. K., Anderson, J. G., Franck, L. S., Gano, D., Petersen, M. A., Oltman, S. P., Chambers, B. D., Neuhaus, J., Rand, L., Jelliffe-Pawlowski, L., & Pantell, M. S. (2021). In Journal of Perinatology (Vols. 41, Issues 7, p. 1782). 10.1038/s41372-021-01004-x
Abstract
Abstract
A Correction to this paper has been published: https://doi.org/10.1038/s41372-021-01004-x.

Gestational age dating using newborn metabolic screening : A validation study in Busia, Uganda

Oltman, S. P., Jasper, E. A., Kajubi, R., Ochieng, T., Kakuru, A., Adrama, H., Okitwi, M., Olwoch, P., Kamya, M., Bedell, B., McCarthy, M., Dagle, J., Jagannathan, P., Clark, T. D., Dorsey, G., Rand, L., Ruel, T., Rogers, E. E., Ryckman, K. K., & Jelliffe-Pawlowski, L. (2021). In Journal of Global Health (Vols. 11, pp. 1-9). 10.7189/jogh.11.04012
Abstract
Abstract
Background Limited ultrasound capacity in low-resource settings makes correct gestational age (GA) dating difficult. Previous work demonstrated that newborn metabolic profiles can accurately determine gestational age, but this relationship has not been evaluated in low-income countries. The objective of this study was to validate and adapt a metabolic GA dating model developed using newborn blood spots for use in a low-resource setting in rural Uganda. Methods A cohort of pregnant women was followed prospectively and heel stick blood spots were collected from 666 newborns in Busia, Uganda at the time of delivery. They were dried, frozen, and shipped to the US where they were tested for 47 metabolites. Metabolic model performance was assessed using early ultrasound determined GA as the standard. Models tested included previously built multivariable models and models specifically adapted to the Busia population. Results The previously built model successfully dated 81.2% of newborns within two weeks of their ultrasound GA. Only 4.8% of GAs were off by greater than three weeks. In the model adapted to the local population, 89.2% of GAs matched their corresponding ultrasound to within two weeks. The model-derived preterm birth rate was 7.2% compared to 5.9% by ultrasound. Conclusions These results suggest that metabolic dating is a reliable method to determine GA in a low-income setting. Metabolic dating offers the potential to better elucidate preterm birth rates in low-resource settings, which is important for assessing population-level patterns, tailoring clinical care, and understanding the developmental trajectories of preterm infants.

Maternal nativity and risk of adverse perinatal outcomes among Black women residing in California, 2011–2017

McKenzie-Sampson, S., Baer, R. J., Blebu, B. E., Karasek, D., Oltman, S. P., Pantell, M. S., Rand, L., Rogers, E. E., Torres, J. M., Jelliffe-Pawlowski, L., Scott, K. A., & Chambers, B. D. (2021). In Journal of Perinatology (Vols. 41, Issues 12, pp. 2736-2741). 10.1038/s41372-021-01149-9
Abstract
Abstract
Objective: Examine the risk of adverse perinatal outcomes among the United States (US)-born and foreign-born Black women in California. Study design: The study comprised all singleton live births to Black women in California between 2011 and 2017. We defined maternal nativity as US-born or foreign-born. Using Poisson regression, we computed risk ratios (RR) and 95% confidence intervals (CI) for three adverse perinatal outcomes: preterm birth, small for gestational age deliveries, and infant mortality. Results: Rates of adverse perinatal outcomes were significantly higher among US-born Black women. In adjusted models, US-born Black women experienced an increased risk of preterm birth (RR 1.51, 95% CI 1.39, 1.65) and small for gestational age deliveries (RR 1.52, 95% CI 1.41, 1.64), compared to foreign-born Black women. Conclusions: Future studies should consider experiences of racism across the life course when exploring heterogeneity in the risk of adverse perinatal outcomes by nativity among Black women in the US.

Media